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Prediction of survival by applying current prognostic models in diffuse large B-cell lymphoma treated with R-CHOP followed by autologous transplantation

 Hong Ghi Lee  ;  Sung-Yong Kim  ;  Inho Kim  ;  Yeo-Kyeoung Kim  ;  Jeong-A Kim  ;  Yang Soo Kim  ;  Ho Sup Lee  ;  Jinny Park  ;  Seok Jin Kim  ;  Hyeok Shim  ;  Hyeon Seok Eom  ;  Byeong-Bae Park  ;  Junglim Lee  ;  Sung Kyu Park  ;  June-Won Cheong  ;  Keon Woo Park 
 BLOOD RESEARCH, Vol.50(3) : 160-166, 2015 
Journal Title
Issue Date
Autologous transplantation ; Diffuse large B-cell lymphoma ; Hematopoietic stem cell transplantation ; Prognostic groups ; Rituximab
BACKGROUND: Among the currently available prognostic models for diffuse large B-cell lymphoma (DLBCL), we investigated to determine which is most adoptable for DLBCL patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) followed by upfront autologous stem cell transplantation (auto-SCT). METHODS: We retrospectively evaluated survival differences among risk groups based on the International Prognostic Index (IPI), the age-adjusted IPI (aaIPI), the revised IPI (R-IPI), and the National Comprehensive Cancer Network IPI (NCCN-IPI) at diagnosis in 63 CD20-positive DLBCL patients treated with R-CHOP followed by upfront auto-SCT. RESULTS: At the time of auto-SCT, 74.6% and 25.4% of patients had achieved complete remission and partial remission after R-CHOP, respectively. As a whole, the 5-year overall (OS) and progression-free survival (PFS) rates were 78.8% and 74.2%, respectively. The 5-year OS and PFS rates according to the IPI, aaIPI, R-IPI, and NCCN-IPI did not significantly differ among the risk groups for each prognostic model (P-values for OS: 0.255, 0.337, 0.881, and 0.803, respectively; P-values for PFS: 0.177, 0.904, 0.295, and 0.609, respectively). CONCLUSION: There was no ideal prognostic model among those currently available for CD20-positive DLBCL patients treated with R-CHOP followed by upfront auto-SCT.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
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