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Prediction of survival by applying current prognostic models in diffuse large B-cell lymphoma treated with R-CHOP followed by autologous transplantation

Authors
 Hong Ghi Lee ; Sung-Yong Kim ; Keon Woo Park ; June-Won Cheong ; Sung Kyu Park ; Junglim Lee ; Byeong-Bae Park ; Hyeon Seok Eom ; Hyeok Shim ; Seok Jin Kim ; Jinny Park ; Ho Sup Lee ; Yang Soo Kim ; Jeong-A Kim ; Yeo-Kyeoung Kim ; Inho Kim 
Citation
 Blood Research, Vol.50(3) : 160~166, 2015 
Journal Title
 Blood Research 
ISSN
 2287-979X 
Issue Date
2015
Abstract
BACKGROUND: Among the currently available prognostic models for diffuse large B-cell lymphoma (DLBCL), we investigated to determine which is most adoptable for DLBCL patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) followed by upfront autologous stem cell transplantation (auto-SCT). METHODS: We retrospectively evaluated survival differences among risk groups based on the International Prognostic Index (IPI), the age-adjusted IPI (aaIPI), the revised IPI (R-IPI), and the National Comprehensive Cancer Network IPI (NCCN-IPI) at diagnosis in 63 CD20-positive DLBCL patients treated with R-CHOP followed by upfront auto-SCT. RESULTS: At the time of auto-SCT, 74.6% and 25.4% of patients had achieved complete remission and partial remission after R-CHOP, respectively. As a whole, the 5-year overall (OS) and progression-free survival (PFS) rates were 78.8% and 74.2%, respectively. The 5-year OS and PFS rates according to the IPI, aaIPI, R-IPI, and NCCN-IPI did not significantly differ among the risk groups for each prognostic model (P-values for OS: 0.255, 0.337, 0.881, and 0.803, respectively; P-values for PFS: 0.177, 0.904, 0.295, and 0.609, respectively). CONCLUSION: There was no ideal prognostic model among those currently available for CD20-positive DLBCL patients treated with R-CHOP followed by upfront auto-SCT.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141717
DOI
10.5045/br.2015.50.3.160
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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