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Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype

Authors
 JE Jang  ;  YH Min  ;  J Yoon  ;  I Kim  ;  J-H Lee  ;  CW Jung  ;  H-J Shin  ;  WS Lee  ;  JH Lee  ;  D-S Hong  ;  H-J Kim  ;  H-J Kim  ;  S Park  ;  K-H Lee  ;  JH Jang  ;  JS Chung  ;  SM Lee  ;  J Park  ;  SK Park  ;  J-S Ahn  ;  W-S Min  ;  J-W Cheong 
Citation
 BLOOD CANCER JOURNAL, Vol.5 : 358, 2015 
Journal Title
 BLOOD CANCER JOURNAL 
Issue Date
2015
MeSH
Abnormal Karyotype ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Asian Continental Ancestry Group ; Combined Modality Therapy ; Cytogenetic Analysis ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Kaplan-Meier Estimate ; Leukemia, Myeloid, Acute/genetics* ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/therapy ; Male ; Middle Aged ; Monosomy/genetics* ; Monosomy/pathology* ; Proportional Hazards Models ; Registries ; Young Adult
Abstract
Monosomal karyotype (MK) defined by either ⩾2 autosomal monosomies or single monosomy with at least one additional structural chromosomal abnormality is associated with a dismal prognosis in patients with acute myeloid leukemia (AML). It was detected in 174 of 3041 AML patients in South Korean Registry. A total of 119 patients who had received induction therapy were finally analyzed to evaluate the predictive factors for a positive prognosis. On multivariate analysis, single monosomy, the absence of abn(17p), ⩾10% of cells with normal metaphase and the achievement of a complete remission (CR) after induction therapy were significant factors for more favorable outcomes. Especially, single monosomy remained as a significantly independent prognostic factor for superior survival in both patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CR and who did not. Allo-HSCT in CR improved overall survival significantly only in patients with a single monosomy. Our results suggest that MK-AML may be biologically different according to the karyotypic subtype and that allo-HSCT in CR should be strongly recommended to patients with a single monosomy. For other patients, more prudent treatment strategies should be examined. Furthermore, the biological mechanism by which a single monosomy influences survival should be investigated.
Files in This Item:
T201504099.pdf Download
DOI
10.1038/bcj.2015.84
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Jang, Ji Eun(장지은) ORCID logo https://orcid.org/0000-0001-8832-1412
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141647
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