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Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype

Authors
 JE Jang  ;  YH Min  ;  J Yoon  ;  I Kim  ;  J-H Lee  ;  CW Jung  ;  H-J Shin  ;  WS Lee  ;  JH Lee  ;  D-S Hong  ;  H-J Kim  ;  H-J Kim  ;  S Park  ;  K-H Lee  ;  JH Jang  ;  JS Chung  ;  SM Lee  ;  J Park  ;  SK Park  ;  J-S Ahn  ;  W-S Min  ;  J-W Cheong 
Citation
 Blood Cancer Journal, Vol.5 : 358-358, 2015 
Journal Title
 Blood Cancer Journal 
ISSN
 2044-5385 
Issue Date
2015
Abstract
Monosomal karyotype (MK) defined by either ⩾2 autosomal monosomies or single monosomy with at least one additional structural chromosomal abnormality is associated with a dismal prognosis in patients with acute myeloid leukemia (AML). It was detected in 174 of 3041 AML patients in South Korean Registry. A total of 119 patients who had received induction therapy were finally analyzed to evaluate the predictive factors for a positive prognosis. On multivariate analysis, single monosomy, the absence of abn(17p), ⩾10% of cells with normal metaphase and the achievement of a complete remission (CR) after induction therapy were significant factors for more favorable outcomes. Especially, single monosomy remained as a significantly independent prognostic factor for superior survival in both patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CR and who did not. Allo-HSCT in CR improved overall survival significantly only in patients with a single monosomy. Our results suggest that MK-AML may be biologically different according to the karyotypic subtype and that allo-HSCT in CR should be strongly recommended to patients with a single monosomy. For other patients, more prudent treatment strategies should be examined. Furthermore, the biological mechanism by which a single monosomy influences survival should be investigated.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141647
DOI
10.1038/bcj.2015.84
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
민유홍(Min, Yoo Hong) ; 장지은(Jang, Ji Eun) ; 정준원(Cheong, June-Won)
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