Cited 11 times in
Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype
DC Field | Value | Language |
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dc.contributor.author | 민유홍 | - |
dc.contributor.author | 장지은 | - |
dc.contributor.author | 정준원 | - |
dc.date.accessioned | 2016-02-04T11:59:26Z | - |
dc.date.available | 2016-02-04T11:59:26Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141647 | - |
dc.description.abstract | Monosomal karyotype (MK) defined by either ⩾2 autosomal monosomies or single monosomy with at least one additional structural chromosomal abnormality is associated with a dismal prognosis in patients with acute myeloid leukemia (AML). It was detected in 174 of 3041 AML patients in South Korean Registry. A total of 119 patients who had received induction therapy were finally analyzed to evaluate the predictive factors for a positive prognosis. On multivariate analysis, single monosomy, the absence of abn(17p), ⩾10% of cells with normal metaphase and the achievement of a complete remission (CR) after induction therapy were significant factors for more favorable outcomes. Especially, single monosomy remained as a significantly independent prognostic factor for superior survival in both patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CR and who did not. Allo-HSCT in CR improved overall survival significantly only in patients with a single monosomy. Our results suggest that MK-AML may be biologically different according to the karyotypic subtype and that allo-HSCT in CR should be strongly recommended to patients with a single monosomy. For other patients, more prudent treatment strategies should be examined. Furthermore, the biological mechanism by which a single monosomy influences survival should be investigated. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e358 | - |
dc.relation.isPartOf | BLOOD CANCER JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Abnormal Karyotype | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Cytogenetic Analysis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/genetics* | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/mortality | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monosomy/genetics* | - |
dc.subject.MESH | Monosomy/pathology* | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Young Adult | - |
dc.title | Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | JE Jang | - |
dc.contributor.googleauthor | YH Min | - |
dc.contributor.googleauthor | J Yoon | - |
dc.contributor.googleauthor | I Kim | - |
dc.contributor.googleauthor | J-H Lee | - |
dc.contributor.googleauthor | CW Jung | - |
dc.contributor.googleauthor | H-J Shin | - |
dc.contributor.googleauthor | WS Lee | - |
dc.contributor.googleauthor | JH Lee | - |
dc.contributor.googleauthor | D-S Hong | - |
dc.contributor.googleauthor | H-J Kim | - |
dc.contributor.googleauthor | H-J Kim | - |
dc.contributor.googleauthor | S Park | - |
dc.contributor.googleauthor | K-H Lee | - |
dc.contributor.googleauthor | JH Jang | - |
dc.contributor.googleauthor | JS Chung | - |
dc.contributor.googleauthor | SM Lee | - |
dc.contributor.googleauthor | J Park | - |
dc.contributor.googleauthor | SK Park | - |
dc.contributor.googleauthor | J-S Ahn | - |
dc.contributor.googleauthor | W-S Min | - |
dc.contributor.googleauthor | J-W Cheong | - |
dc.identifier.doi | 10.1038/bcj.2015.84 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A03477 | - |
dc.contributor.localId | A03729 | - |
dc.relation.journalcode | J00342 | - |
dc.identifier.eissn | 2044-5385 | - |
dc.identifier.pmid | 26473530 | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Jang, Ji Eun | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Jang, Ji Eun | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 5 | - |
dc.citation.startPage | 358 | - |
dc.identifier.bibliographicCitation | BLOOD CANCER JOURNAL, Vol.5 : 358, 2015 | - |
dc.identifier.rimsid | 30791 | - |
dc.type.rims | ART | - |
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