0 160

Cited 9 times in

Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease

 Jee Hyun Ham  ;  Jungho Cha  ;  Jae Jung Lee  ;  Gwang-Min Baek  ;  Mun Kyung Sunwoo  ;  Jin Yong Hong  ;  Na-Young Shin  ;  Young Ho Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
 Neuroimage, Vol.119 : 296-304, 2015 
Journal Title
Issue Date
As an indicator of synchronous neural activity, resting-state functional networks are influenced by neuropathological and neurochemical changes in degenerative diseases. To further advance understanding about neurochemical and neuropathological basis for resting-state functional maps, we performed a comparative analysis of resting-state functional connectivity in patients with Parkinson's disease (PD) and drug induced parkinsonism (DIP). Resting-state neuroimaging data were analyzed with a seed-based approach to investigate striatocortical functional connectivity and cortical functional connectivity within the default mode network, executive control network, and the dorsal attention network. The striatal subregions were divided into the more or less affected sides in terms of dopamine transporter uptake. Compared with DIP, PD exhibited an increased cerebellar connectivity from the more affected side of the caudate and the less affected sides of the anterior and the posterior putamen. Additionally, PD showed increased functional connectivity in the anterior prefrontal areas from the more affected side of the anterior putamen and from the less affected side of the posterior putamen. However, PD exhibited decreased cortical functional connectivity from the posterior cingulate cortex in the left temporal area. Finally, DIP patients showed decreased cortical functional connectivity from the dorsolateral prefrontal cortex in frontal and parietal areas compared with PD patients. In summary, the present study demonstrates that PD patients exhibited a unique resting state functional connectivity that may be associated with PD-related pathological changes beyond the dopaminergic system, whereas DIP patients showed altered functional connectivity within executive control network.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
이재정(Lee, Jae Jung)
이필휴(Lee, Phil Hyu) ORCID logo https://orcid.org/0000-0001-9931-8462
함지현(Ham, Jee Hyun)
홍진용(Hong, Jin Yong)
RIS (EndNote)
XLS (Excel)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.