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Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease

DC FieldValueLanguage
dc.contributor.author손영호-
dc.contributor.author이재정-
dc.contributor.author이필휴-
dc.contributor.author함지현-
dc.contributor.author홍진용-
dc.date.accessioned2016-02-04T11:59:20Z-
dc.date.available2016-02-04T11:59:20Z-
dc.date.issued2015-
dc.identifier.issn1053-8119-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141643-
dc.description.abstractAs an indicator of synchronous neural activity, resting-state functional networks are influenced by neuropathological and neurochemical changes in degenerative diseases. To further advance understanding about neurochemical and neuropathological basis for resting-state functional maps, we performed a comparative analysis of resting-state functional connectivity in patients with Parkinson's disease (PD) and drug induced parkinsonism (DIP). Resting-state neuroimaging data were analyzed with a seed-based approach to investigate striatocortical functional connectivity and cortical functional connectivity within the default mode network, executive control network, and the dorsal attention network. The striatal subregions were divided into the more or less affected sides in terms of dopamine transporter uptake. Compared with DIP, PD exhibited an increased cerebellar connectivity from the more affected side of the caudate and the less affected sides of the anterior and the posterior putamen. Additionally, PD showed increased functional connectivity in the anterior prefrontal areas from the more affected side of the anterior putamen and from the less affected side of the posterior putamen. However, PD exhibited decreased cortical functional connectivity from the posterior cingulate cortex in the left temporal area. Finally, DIP patients showed decreased cortical functional connectivity from the dorsolateral prefrontal cortex in frontal and parietal areas compared with PD patients. In summary, the present study demonstrates that PD patients exhibited a unique resting state functional connectivity that may be associated with PD-related pathological changes beyond the dopaminergic system, whereas DIP patients showed altered functional connectivity within executive control network.-
dc.description.statementOfResponsibilityopen-
dc.format.extent296~304-
dc.relation.isPartOfNeuroimage-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleNigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorJee Hyun Ham-
dc.contributor.googleauthorJungho Cha-
dc.contributor.googleauthorJae Jung Lee-
dc.contributor.googleauthorGwang-Min Baek-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorNa-Young Shin-
dc.contributor.googleauthorYoung Ho Sohn-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1016/j.neuroimage.2015.06.077-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01982-
dc.contributor.localIdA03082-
dc.contributor.localIdA03270-
dc.contributor.localIdA04338-
dc.contributor.localIdA04442-
dc.relation.journalcodeJ02332-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1053811915005820-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Jae Jung-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Jae Jung-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.rights.accessRightsnot free-
dc.citation.volume119-
dc.citation.startPage296-
dc.citation.endPage304-
dc.identifier.bibliographicCitationNeuroimage, Vol.119 : 296-304, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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