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Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease

Authors
 Jee Hyun Ham  ;  Jungho Cha  ;  Jae Jung Lee  ;  Gwang-Min Baek  ;  Mun Kyung Sunwoo  ;  Jin Yong Hong  ;  Na-Young Shin  ;  Young Ho Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
Citation
 Neuroimage, Vol.119 : 296-304, 2015 
Journal Title
 Neuroimage 
ISSN
 1053-8119 
Issue Date
2015
MeSH
Aged ; Brain Mapping ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Corpus Striatum/physiopathology* ; Dopamine/metabolism* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nerve Net/diagnostic imaging ; Nerve Net/metabolism ; Nerve Net/physiopathology ; Neural Pathways/metabolism ; Neural Pathways/physiopathology ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Parkinson Disease/physiopathology* ; Parkinson Disease, Secondary/diagnostic imaging ; Parkinson Disease, Secondary/metabolism ; Parkinson Disease, Secondary/physiopathology* ; Positron-Emission Tomography ; Substantia Nigra/diagnostic imaging ; Substantia Nigra/metabolism ; Substantia Nigra/physiopathology* ; Tropanes
Keywords
Dopamine independent network ; Drug induced parkinsonism ; Parkinson's disease ; Resting-state functional connectivity
Abstract
As an indicator of synchronous neural activity, resting-state functional networks are influenced by neuropathological and neurochemical changes in degenerative diseases. To further advance understanding about neurochemical and neuropathological basis for resting-state functional maps, we performed a comparative analysis of resting-state functional connectivity in patients with Parkinson's disease (PD) and drug induced parkinsonism (DIP). Resting-state neuroimaging data were analyzed with a seed-based approach to investigate striatocortical functional connectivity and cortical functional connectivity within the default mode network, executive control network, and the dorsal attention network. The striatal subregions were divided into the more or less affected sides in terms of dopamine transporter uptake. Compared with DIP, PD exhibited an increased cerebellar connectivity from the more affected side of the caudate and the less affected sides of the anterior and the posterior putamen. Additionally, PD showed increased functional connectivity in the anterior prefrontal areas from the more affected side of the anterior putamen and from the less affected side of the posterior putamen. However, PD exhibited decreased cortical functional connectivity from the posterior cingulate cortex in the left temporal area. Finally, DIP patients showed decreased cortical functional connectivity from the dorsolateral prefrontal cortex in frontal and parietal areas compared with PD patients. In summary, the present study demonstrates that PD patients exhibited a unique resting state functional connectivity that may be associated with PD-related pathological changes beyond the dopaminergic system, whereas DIP patients showed altered functional connectivity within executive control network.
Full Text
http://www.sciencedirect.com/science/article/pii/S1053811915005820
DOI
10.1016/j.neuroimage.2015.06.077
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Ham, Jee Hyun(함지현)
Hong, Jin Yong(홍진용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141643
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