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Apathy and olfactory dysfunction in early Parkinson's disease

Authors
 Jin Yong Hong  ;  Mun Kyung Sunwoo  ;  Jee Hyun Ham  ;  Jae Jung Lee  ;  Phil Hyu Lee  ;  Young H Sohn 
Citation
 Journal of Movement Disorders, Vol.8(1) : 21-25, 2015 
Journal Title
 Journal of Movement Disorders 
ISSN
 2005-940X 
Issue Date
2015
Abstract
OBJECTIVE: Olfactory and emotional dysfunctions are very common in patients with Parkinson's disease (PD). Olfaction and emotions share common neuroanatomical substrates. Therefore, in this study, we evaluated the association between olfactory and emotional dysfunctions in patients with PD. METHODS: Parkinson's disease patients who had been assessed for their olfactory function and neuropsychiatric symptoms including emotional dysfunction were included. A logistic regression analysis was performed to evaluate the association between low olfaction and different neuropsychiatric symptoms. RESULTS: The patients with low olfaction (cross cultural smell identification test score ≤ 6) showed a higher prevalence of apathy when compared with those with high olfaction, whereas the frequencies of other neuropsychiatric symptoms were comparable between the two groups. A multivariate logistic regression analysis revealed that the presence of apathy/indifference [odds ratio (OR) = 2.859, p = 0.007], age 70 years or more (OR = 2.281, p = 0.009), and the male gender (OR = 1.916, p = 0.030) were significantly associated with low olfaction. CONCLUSIONS: Our results demonstrate that apathy/indifference is a unique emotional dysfunction associated with olfactory dysfunction in PD. The findings also suggest that PD patients with low olfaction have a high prevalence of apathy.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141637
DOI
10.14802/jmd.14029
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
선우문경(Sunwoo, Mun Kyung) ; 손영호(Sohn, Young Ho) ; 이재정(Lee, Jae Jung) ; 이필휴(Lee, Phil Hyu) ; 함지현(Ham, Jee Hyun) ; 홍진용(Hong, Jin Yong)
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