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Apathy and olfactory dysfunction in early Parkinson's disease

DC FieldValueLanguage
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이재정-
dc.contributor.author이필휴-
dc.contributor.author함지현-
dc.contributor.author홍진용-
dc.date.accessioned2016-02-04T11:59:10Z-
dc.date.available2016-02-04T11:59:10Z-
dc.date.issued2015-
dc.identifier.issn2093-4939-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141637-
dc.description.abstractOBJECTIVE: Olfactory and emotional dysfunctions are very common in patients with Parkinson's disease (PD). Olfaction and emotions share common neuroanatomical substrates. Therefore, in this study, we evaluated the association between olfactory and emotional dysfunctions in patients with PD. METHODS: Parkinson's disease patients who had been assessed for their olfactory function and neuropsychiatric symptoms including emotional dysfunction were included. A logistic regression analysis was performed to evaluate the association between low olfaction and different neuropsychiatric symptoms. RESULTS: The patients with low olfaction (cross cultural smell identification test score ≤ 6) showed a higher prevalence of apathy when compared with those with high olfaction, whereas the frequencies of other neuropsychiatric symptoms were comparable between the two groups. A multivariate logistic regression analysis revealed that the presence of apathy/indifference [odds ratio (OR) = 2.859, p = 0.007], age 70 years or more (OR = 2.281, p = 0.009), and the male gender (OR = 1.916, p = 0.030) were significantly associated with low olfaction. CONCLUSIONS: Our results demonstrate that apathy/indifference is a unique emotional dysfunction associated with olfactory dysfunction in PD. The findings also suggest that PD patients with low olfaction have a high prevalence of apathy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent21~25-
dc.relation.isPartOfJOURNAL OF MOVEMENT DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleApathy and olfactory dysfunction in early Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorJee Hyun Ham-
dc.contributor.googleauthorJae Jung Lee-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYoung H Sohn-
dc.identifier.doi10.14802/jmd.14029-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03082-
dc.contributor.localIdA03270-
dc.contributor.localIdA04338-
dc.contributor.localIdA04442-
dc.relation.journalcodeJ01610-
dc.identifier.eissn2005-940X-
dc.identifier.pmid25614782-
dc.subject.keywordApathy-
dc.subject.keywordEmotion-
dc.subject.keywordHyposmia-
dc.subject.keywordNeuropsychiatric-
dc.subject.keywordParkinson’s disease-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Jae Jung-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Jae Jung-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage21-
dc.citation.endPage25-
dc.identifier.bibliographicCitationJOURNAL OF MOVEMENT DISORDERS, Vol.8(1) : 21-25, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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