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PTK7+ Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1.

DC FieldValueLanguage
dc.contributor.author이형근-
dc.contributor.author정은애-
dc.date.accessioned2016-02-04T11:59:06Z-
dc.date.available2016-02-04T11:59:06Z-
dc.date.issued2015-
dc.identifier.issn1079-5642-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141634-
dc.description.abstractOBJECTIVE: In angiogenesis, circulating mononuclear cells are recruited to vascular lesions; however, the underlying mechanisms are poorly understood. APPROACH AND RESULTS: Here, we characterize the functional role of protein tyrosine kinase 7 (PTK7)-expressing CD11b(+) mononuclear cells in vitro and in vivo using a mouse model of angiogenesis. Although the frequencies of PTK7(+)CD11b(+) cells in the bone marrow remained similar after vascular endothelial growth factor-A-induced neovascularization, we observed an 11-fold increase in the cornea. Importantly, vascular endothelial growth factor-A-induced chemotaxis of PTK7(+) cells was mediated by vascular endothelial growth factor receptor 2. In a coculture with endothelial cells, PTK7(+)CD11b(+) cells stabilized the vascular network for 2 weeks by expressing high levels of angiopoietin-1. The enhanced vascular stability was abolished by knockdown of angiopoietin-1 in PTK7(+)CD11b(+) cells and could be restored by angiopoietin-1 treatment. CONCLUSIONS: We conclude that PTK7 expression in perivascular mononuclear cells induces vascular endothelial growth factor receptor 2 and angiopoietin-1 expression and thus contributes to vascular stabilization in angiogenesis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1606~1615-
dc.relation.isPartOfArteriosclerosis Thromobosis and Vascular Biology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePTK7+ Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorSunil K. Chauhan-
dc.contributor.googleauthorHyung Keun Lee-
dc.contributor.googleauthorHyun Soo Lee-
dc.contributor.googleauthorEun Young Park-
dc.contributor.googleauthorEunae Jeong-
dc.contributor.googleauthorReza Dana-
dc.identifier.doi10.1161/ATVBAHA.114.305228-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03303-
dc.contributor.localIdA03687-
dc.relation.journalcodeJ00238-
dc.identifier.urlhttp://atvb.ahajournals.org/content/35/7/1606.long-
dc.contributor.alternativeNameLee, Hyung Keun-
dc.contributor.alternativeNameJeong, Eun Ae-
dc.contributor.affiliatedAuthorLee, Hyung Keun-
dc.contributor.affiliatedAuthorJeong, Eun Ae-
dc.rights.accessRightsnot free-
dc.citation.volume35-
dc.citation.number7-
dc.citation.startPage1606-
dc.citation.endPage1615-
dc.identifier.bibliographicCitationArteriosclerosis Thromobosis and Vascular Biology, Vol.35(7) : 1606-1615, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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