Cited 10 times in
PTK7+ Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1.
DC Field | Value | Language |
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dc.contributor.author | 이형근 | - |
dc.contributor.author | 정은애 | - |
dc.date.accessioned | 2016-02-04T11:59:06Z | - |
dc.date.available | 2016-02-04T11:59:06Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1079-5642 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141634 | - |
dc.description.abstract | OBJECTIVE: In angiogenesis, circulating mononuclear cells are recruited to vascular lesions; however, the underlying mechanisms are poorly understood. APPROACH AND RESULTS: Here, we characterize the functional role of protein tyrosine kinase 7 (PTK7)-expressing CD11b(+) mononuclear cells in vitro and in vivo using a mouse model of angiogenesis. Although the frequencies of PTK7(+)CD11b(+) cells in the bone marrow remained similar after vascular endothelial growth factor-A-induced neovascularization, we observed an 11-fold increase in the cornea. Importantly, vascular endothelial growth factor-A-induced chemotaxis of PTK7(+) cells was mediated by vascular endothelial growth factor receptor 2. In a coculture with endothelial cells, PTK7(+)CD11b(+) cells stabilized the vascular network for 2 weeks by expressing high levels of angiopoietin-1. The enhanced vascular stability was abolished by knockdown of angiopoietin-1 in PTK7(+)CD11b(+) cells and could be restored by angiopoietin-1 treatment. CONCLUSIONS: We conclude that PTK7 expression in perivascular mononuclear cells induces vascular endothelial growth factor receptor 2 and angiopoietin-1 expression and thus contributes to vascular stabilization in angiogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1606~1615 | - |
dc.relation.isPartOf | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | PTK7+ Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Sunil K. Chauhan | - |
dc.contributor.googleauthor | Hyung Keun Lee | - |
dc.contributor.googleauthor | Hyun Soo Lee | - |
dc.contributor.googleauthor | Eun Young Park | - |
dc.contributor.googleauthor | Eunae Jeong | - |
dc.contributor.googleauthor | Reza Dana | - |
dc.identifier.doi | 10.1161/ATVBAHA.114.305228 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03303 | - |
dc.contributor.localId | A03687 | - |
dc.relation.journalcode | J00238 | - |
dc.identifier.eissn | 1524-4636 | - |
dc.identifier.url | http://atvb.ahajournals.org/content/35/7/1606.long | - |
dc.subject.keyword | angiopoietin-1 | - |
dc.subject.keyword | PTK7 protein, mouse | - |
dc.subject.keyword | VEGFR2 protein, mouse | - |
dc.contributor.alternativeName | Lee, Hyung Keun | - |
dc.contributor.alternativeName | Jeong, Eun Ae | - |
dc.contributor.affiliatedAuthor | Lee, Hyung Keun | - |
dc.contributor.affiliatedAuthor | Jeong, Eun Ae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1606 | - |
dc.citation.endPage | 1615 | - |
dc.identifier.bibliographicCitation | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol.35(7) : 1606-1615, 2015 | - |
dc.identifier.rimsid | 30782 | - |
dc.type.rims | ART | - |
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