0 236

Cited 13 times in

Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system

 Minkyung Lee  ;  Young Hoon Ryu  ;  Won Gil Cho  ;  Yeo Wool Kang  ;  Soo Jin Lee  ;  Tae Joo Jeon  ;  Chul Hyoung Lyoo  ;  Chul Hoon Kim  ;  Dong Goo Kim  ;  Kyochul Lee  ;  Tae Hyun Choi  ;  Jae Yong Choi 
 SYNAPSE, Vol.69(9) : 453-460, 2015 
Journal Title
Issue Date
Animals ; Brain/diagnostic imaging ; Brain/drug effects ; Brain/metabolism* ; Depressive Disorder/diagnostic imaging ; Depressive Disorder/metabolism* ; Disease Models, Animal ; Dopamine/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism* ; Dopaminergic Neurons/diagnostic imaging ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism* ; Movement Disorders/diagnostic imaging ; Movement Disorders/metabolism* ; Oxidopamine ; Piperazines ; Positron-Emission Tomography ; Pyridines ; Radiopharmaceuticals ; Rats, Sprague-Dawley ; Receptor, Serotonin, 5-HT1A/metabolism* ; Serotonin/metabolism ; Tropanes
6-hydroxydopamine ; PET ; Parkinson's disease ; depression
Depression frequently accompanies in Parkinson's disease (PD). Previous research suggested that dopamine (DA) and serotonin systems are closely linked with depression in PD. However, comprehensive studies about the relationship between these two neurotransmitter systems are limited. Therefore, the purpose of this study is to evaluate the effect of dopaminergic destruction on the serotonin system. The interconnection between motor and depression was also examined. Two PET scans were performed in the 6-hydroxydopamine (6-OHDA) lesioned and sham operated rats: [(18) F]FP-CIT for DA transporters and [(18) F]Mefway for serotonin 1A (5-HT(1A)) receptors. Here, 6-OHDA is a neurotoxin for dopaminergic neurons. Behavioral tests were used to evaluate the severity of symptoms: rotational number for motor impairment and immobility time, acquired from the forced swim test for depression. Region-of-interests were drawn in the striatum and cerebellum for the DA system and hippocampus and cerebellum for the 5-HT system. The cerebellum was chosen as a reference region. Nondisplaceable binding potential in the striatum and hippocampus were compared between 6-OHDA and sham groups. As a result, the degree of DA depletion was negatively correlated with rotational behavior (R(2)  = 0.79, P = 0.003). In 6-OHDA lesioned rats, binding values for 5-HT(1A) receptors was 22% lower than the sham operated group. This decrement of 5-HT(1A) receptor binding was also correlated with the severity of depression (R(2)  = 0.81, P = 0.006). Taken together, this research demonstrated that the destruction of dopaminergic system causes the reduction of the serotonergic system resulting in the expression of depressive behavior. The degree of dopaminergic dysfunction was positively correlated with the impairment of the serotonin system. Severity of motor symptoms was also closely related to depressive behavior.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Min Kyung(이민경)
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.