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Response to Switch from Intermittent Therapy to Daily Therapy for Refractory Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease

Authors
 Won-Jung Koh  ;  Byeong-Ho Jeong  ;  Kyeongman Jeon  ;  Hye Yun Park  ;  Su-Young Kim  ;  Hee Jae Huh  ;  Chang-Seok Ki  ;  Nam Yong Lee  ;  Sung Jae Shin  ;  Charles L. Daley 
Citation
 ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, Vol.59(8) : 4994-4996, 2015 
Journal Title
 ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 
ISSN
 1871-5206 
Issue Date
2015
MeSH
Aged ; Anti-Bacterial Agents/administration & dosage* ; Bronchiectasis/drug therapy* ; Bronchiectasis/microbiology* ; Clarithromycin/administration & dosage ; Drug Therapy, Combination/methods ; Ethambutol/administration & dosage ; Female ; Humans ; Lung/microbiology ; Lung Diseases/diet therapy* ; Lung Diseases/microbiology* ; Male ; Middle Aged ; Mycobacterium avium Complex/drug effects* ; Mycobacterium avium-intracellulare Infection/drug therapy* ; Sputum/microbiology
Abstract
Intermittent three-times-weekly antibiotic therapy is recommended for the initial treatment of patients with noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease. Although some experts recommend switching from intermittent to daily therapy for patients whose sputum has persistent positive cultures after intermittent therapy, the clinical efficacy of these modifications is unknown. Of 20 patients whose sputum had persistent positive cultures after 12 months of intermittent antibiotic therapy, specimens from 6 patients (30%) achieved a negative culture after a change to daily therapy.
Full Text
http://aac.asm.org/content/59/8/4994.long
DOI
10.1128/AAC.00648-15
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141346
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