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Response to Switch from Intermittent Therapy to Daily Therapy for Refractory Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease

Authors
 Won-Jung Koh ; Byeong-Ho Jeong ; Charles L. Daley ; Sung Jae Shin ; Nam Yong Lee ; Chang-Seok Ki ; Hee Jae Huh ; Su-Young Kim ; Hye Yun Park ; Kyeongman Jeon 
Citation
 Anti-Cancer Agents in Medicinal Chemistry, Vol.59(8) : 4994~4996, 2015 
Journal Title
 Anti-Cancer Agents in Medicinal Chemistry 
ISSN
 0066-4804 
Issue Date
2015
Abstract
Intermittent three-times-weekly antibiotic therapy is recommended for the initial treatment of patients with noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease. Although some experts recommend switching from intermittent to daily therapy for patients whose sputum has persistent positive cultures after intermittent therapy, the clinical efficacy of these modifications is unknown. Of 20 patients whose sputum had persistent positive cultures after 12 months of intermittent antibiotic therapy, specimens from 6 patients (30%) achieved a negative culture after a change to daily therapy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141346
DOI
10.1128/AAC.00648-15
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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Link
 http://aac.asm.org/content/59/8/4994.long
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