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Accuracy of transient elastography in assessing liver fibrosis in chronic viral hepatitis: A multicentre, retrospective study

Authors
 Yeon Seok Seo  ;  Moon Young Kim  ;  Seung Up Kim  ;  Bae Si Hyun  ;  Jae Young Jang  ;  Jin Woo Lee  ;  Jung Il Lee  ;  Sang Jun Suh  ;  Soo Young Park  ;  Hana Park  ;  Eun Uk Jung  ;  Byung Seok Kim  ;  In Hee Kim  ;  Tae Hee Lee  ;  Soon Ho Um  ;  Kwang-Hyub Han  ;  Sang Gyune Kim  ;  Soon Koo Paik  ;  Jong Young Choi  ;  Soung Won Jeong  ;  Young Joo Jin  ;  Kwan Sik Lee  ;  Hyung Joon Yim  ;  Won Young Tak  ;  Seong Gyu Hwang  ;  Youn Jae Lee  ;  Chang Hyeong Lee  ;  Dae-Ghon Kim  ;  Young Woo Kang  ;  Young Seok Kim 
Citation
 Liver International, Vol.35(10) : 2246-2255, 2015 
Journal Title
 Liver International 
ISSN
 1478-3223 
Issue Date
2015
Abstract
BACKGROUND/AIMS: Transient elastography (TE) has become an alternative to liver biopsy (LB). This study investigated the diagnostic performance of liver stiffness (LS) measurement using TE in Korean patients with chronic hepatitis B and C (CHB and CHC). METHODS: From April 2006 to June 2014, 916 patients (567 CHB and 349 CHC) who underwent LB and TE at 15 centres were analyzed. The Batts and Ludwig scoring system was used for histologic assessment. Aspartate aminotransferase (AST)-to-platelet ratio indexes (APRI) were calculated. Area under the receiver operating characteristic curve (AUROC) was used. RESULTS: The median age, LS value, and APRI score were 45 years, 8.8 kPa, and 0.61, respectively, in CHB patients vs. 51 years, 6.8 kPa and 0.55, respectively, in CHC patients. TE was significantly superior to APRI in CHB patients (AUROC 0.774 vs. 0.72 for ≥F2, 0.849 vs. 0.812 for ≥F3, and 0.902 vs. 0.707 for F4, respectively; all P < 0.05). Furthermore, TE was significantly superior for predicting ≥ F3 stage (AUROC 0.865 vs. 0.840, P = 0.009) whereas it was similar for predicting ≥ F2 and F4 stage (AUROC 0.822 vs. 0.796; 0.910 vs. 0.884; all P > 0.05) in CHC patients. In CHB patients, optimal cut-off LS values were 7.8 kPa for ≥F2, 8.2 kPa for ≥ F3, and 11.6 kPa for F4, vs. 6.8 kPa, 8.6 kPa, and 14.5 kPa, respectively, in CHC patients. CONCLUSIONS: TE can accurately assess the degree of liver fibrosis in Korean patients with CVH. TE was superior to APRI for predicting each fibrosis stage.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141322
DOI
10.1111/liv.12808
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김승업(Kim, Seung Up) ; 이관식(Lee, Kwan Sik) ; 이정일(Lee, Jung Il) ; 한광협(Han, Kwang Hyup)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/liv.12808/abstract
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