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Accuracy of transient elastography in assessing liver fibrosis in chronic viral hepatitis: A multicentre, retrospective study

 Yeon Seok Seo  ;  Moon Young Kim  ;  Seung Up Kim  ;  Bae Si Hyun  ;  Jae Young Jang  ;  Jin Woo Lee  ;  Jung Il Lee  ;  Sang Jun Suh  ;  Soo Young Park  ;  Hana Park  ;  Eun Uk Jung  ;  Byung Seok Kim  ;  In Hee Kim  ;  Tae Hee Lee  ;  Soon Ho Um  ;  Kwang-Hyub Han  ;  Sang Gyune Kim  ;  Soon Koo Paik  ;  Jong Young Choi  ;  Soung Won Jeong  ;  Young Joo Jin  ;  Kwan Sik Lee  ;  Hyung Joon Yim  ;  Won Young Tak  ;  Seong Gyu Hwang  ;  Youn Jae Lee  ;  Chang Hyeong Lee  ;  Dae-Ghon Kim  ;  Young Woo Kang  ;  Young Seok Kim 
 LIVER INTERNATIONAL, Vol.35(10) : 2246-2255, 2015 
Journal Title
Issue Date
Adult ; Area Under Curve ; Biomarkers/analysis* ; Biopsy ; Elasticity Imaging Techniques/methods* ; Female ; Hepatitis B, Chronic/complications* ; Hepatitis C, Chronic/complications* ; Humans ; Liver/pathology* ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/pathology ; Male ; Middle Aged ; Multivariate Analysis ; ROC Curve ; Republic of Korea ; Retrospective Studies
Fibroscan ; Transient elastography ; chronic liver disease ; cirrhosis ; liver fibrosis ; liver stiffness ; performance
BACKGROUND/AIMS: Transient elastography (TE) has become an alternative to liver biopsy (LB). This study investigated the diagnostic performance of liver stiffness (LS) measurement using TE in Korean patients with chronic hepatitis B and C (CHB and CHC). METHODS: From April 2006 to June 2014, 916 patients (567 CHB and 349 CHC) who underwent LB and TE at 15 centres were analyzed. The Batts and Ludwig scoring system was used for histologic assessment. Aspartate aminotransferase (AST)-to-platelet ratio indexes (APRI) were calculated. Area under the receiver operating characteristic curve (AUROC) was used. RESULTS: The median age, LS value, and APRI score were 45 years, 8.8 kPa, and 0.61, respectively, in CHB patients vs. 51 years, 6.8 kPa and 0.55, respectively, in CHC patients. TE was significantly superior to APRI in CHB patients (AUROC 0.774 vs. 0.72 for ≥F2, 0.849 vs. 0.812 for ≥F3, and 0.902 vs. 0.707 for F4, respectively; all P < 0.05). Furthermore, TE was significantly superior for predicting ≥ F3 stage (AUROC 0.865 vs. 0.840, P = 0.009) whereas it was similar for predicting ≥ F2 and F4 stage (AUROC 0.822 vs. 0.796; 0.910 vs. 0.884; all P > 0.05) in CHC patients. In CHB patients, optimal cut-off LS values were 7.8 kPa for ≥F2, 8.2 kPa for ≥ F3, and 11.6 kPa for F4, vs. 6.8 kPa, 8.6 kPa, and 14.5 kPa, respectively, in CHC patients. CONCLUSIONS: TE can accurately assess the degree of liver fibrosis in Korean patients with CVH. TE was superior to APRI for predicting each fibrosis stage.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Jung Il(이정일) ORCID logo https://orcid.org/0000-0002-0142-1398
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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