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Punctate hyperfluorescent spots associated with polypoidal choroidal vasculopathy on indocyanine green angiography

Authors
 Hyesun Kim  ;  Ji Hwan Lee  ;  Kye Yoon Kwon  ;  Suk Ho Byeon  ;  Sung Chul Lee  ;  Christopher Seungkyu Lee 
Citation
 OPHTHALMIC SURGERY LASERS & IMAGING RETINA, Vol.46(4) : 423-427, 2015 
Journal Title
 OPHTHALMIC SURGERY LASERS & IMAGING RETINA 
ISSN
 2325-8160 
Issue Date
2015
MeSH
Aged ; Aged, 80 and over ; Capillary Permeability ; Choroid/blood supply* ; Choroid/pathology* ; Choroidal Neovascularization/diagnosis* ; Coloring Agents* ; Exudates and Transudates ; Female ; Fluorescein Angiography ; Humans ; Indocyanine Green* ; Male ; Middle Aged ; Polyps/diagnosis* ; Retrospective Studies
Abstract
BACKGROUND AND OBJECTIVE: To evaluate punctate hyperfluorescent spots on indocyanine green angiography (ICGA) in eyes with polypoidal choroidal vasculopathy (PCV). PATIENTS AND METHODS: Retrospective observation case series of 88 eyes of 81 patients (63 men and 18 women) analyzing fundus photography, fluorescein angiography, ICGA, and spectral-domain optical coherence tomography (OCT) findings at baseline. RESULTS: Seven patients (9%) had bilateral PCV lesions. Mean age was 68.44 ± 5.94 years (range: 45 to 86 years). Macular-type PCV was found in 72 eyes (81.8%), peripapillary-type PCV in 12 eyes (13.6%), and combined-type PCV in four eyes (4.5%). Choroidal vascular hyperpermeability was observed in 38 eyes (43.2%), and punctate hyperfluorescent spots on ICGA in 47 eyes (53.4%). ICGA of unaffected fellow eyes of 74 patients with unilateral PCV revealed choroidal hyperpermeability in 23 eyes (31.1%) and punctate hyperfluorescent spots in 38 eyes (51.4%). Presence of punctate hyperfluorescent spots was significantly associated with choroidal vascular hyperpermeability (P < .001). CONCLUSION: Punctate hyperfluorescent spots were frequently observed in eyes with PCV in late-phase ICGA, as previously described in eyes with central serous chorioretinopathy, which may represent leakage from punctate hyperpermeable inner choroid spots or late staining of forme fruste drusen or drusen-like subretinal pigment epithelium deposits associated with choroidal hyperpermeability.
Full Text
http://www.healio.com/ophthalmology/journals/osli/2015-4-46-4/%7B52043214-ab26-4ffb-9332-96479bc051b1%7D/punctate-hyperfluorescent-spots-associated-with-polypoidal-choroidal-vasculopathy-on-indocyanine-green-angiography
DOI
10.3928/23258160-20150422-04
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Ji Hwan(이지환) ORCID logo https://orcid.org/0000-0003-1759-8195
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141285
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