Cited 0 times in

214 9

Comparison of adhesion and dissolution of fentanyl patches: Fentadur® and Durogesic DTrans®

Authors
 Taek Sun Kim ; Su Eon Jin ; Sung Joo Hwang ; Min Soo Kim ; Bokyung Sun 
Citation
 Journal of Pharmaceutical Investigation, Vol.45(5) : 475~480, 2015 
Journal Title
 Journal of Pharmaceutical Investigation 
ISSN
 2093-5552 
Issue Date
2015
Abstract
Fentanyl is a potent opioid used as an analgesic for pain therapy. Fentanyl patches have been developed using patch design technologies that use the transdermal route. The aim of this study was to compare the adhesion and dissolution properties of two fentanyl patches, Fentadur® (Pfizer Inc., USA) and Durogesic DTrans® (Janssen-Cilag, Inc., USA), which were designed as a reservoir and a matrix, respectively. For the characterization of fentanyl patches, a 180° peel adhesion test and a dissolution test were performed at 12 and 100 μg/h of fentanyl patches. Specifically, the dissolution of fentanyl patches was tested at 32 and 40 °C using the USP apparatus 6 and the released fentanyl was analyzed using LC–MS/MS. Fentadur® and Durogesic DTrans® had acceptable adhesion forces over 150 gf using 12 mm of fentanyl patches. Comparing adhesion forces of Fentadur® and Durogesic DTrans®, Fentadur® had lower adhesion force values than Durogesic DTrans®. The release of fentanyl in Fentadur® was lower than that in Durogesic DTrans®, except for 100 μg/h Fentadur® at 40 °C over 12–48 h. The results show that Fentadur® and Durogesic DTrans® had the different properties of adhesion and dissolution, which could be critical factors for the prediction of clinical use.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141215
DOI
10.1007/s40005-015-0195-y
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Institute of vision research
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://link.springer.com/article/10.1007/s40005-015-0195-y
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse