Cited 8 times in
Hepatic fat quantification magnetic resonance for monitoring treatment response in pediatric nonalcoholic steatohepatitis
DC Field | Value | Language |
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dc.contributor.author | 김명준 | - |
dc.contributor.author | 김승 | - |
dc.contributor.author | 김현지 | - |
dc.contributor.author | 신현주 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 고홍 | - |
dc.date.accessioned | 2016-02-04T11:47:34Z | - |
dc.date.available | 2016-02-04T11:47:34Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141213 | - |
dc.description.abstract | To evaluate the possibility of treatment effect monitoring using hepatic fat quantification magnetic resonance (MR) in pediatric nonalcoholic steatohepatitis (NASH). METHODS: We retrospectively reviewed the medical records of patients who received educational recommendations and vitamin E for NASH and underwent hepatic fat quantification MR from 2011 to 2013. Hepatic fat fraction (%) was measured using dual- and triple-echo gradient-recalled-echo sequences at 3T. The compliant and non-compliant groups were compared clinically, biochemically, and radiologically. RESULTS: Twenty seven patients (M:F = 24:3; mean age: 12 ± 2.3 years) were included (compliant group = 22, non-compliant = 5). None of the baseline findings differed between the 2 groups, except for triglyceride level (compliant vs non-compliant, 167.7 mg/dL vs 74.2 mg/dL, P = 0.001). In the compliant group, high-density lipoprotein increased and all other parameters decreased after 1-year follow-up. However, there were various changes in the non-compliant group. Dual-echo fat fraction (-19.2% vs 4.6, P < 0.001), triple-echo fat fraction (-13.4% vs 3.5, P < 0.001), alanine aminotransferase (-110.7 IU/L vs -10.6 IU/L, P = 0.047), total cholesterol (-18.1 mg/dL vs 3.8 mg/dL, P = 0.016), and triglyceride levels (-61.3 mg/dL vs 11.2 mg/dL, P = 0.013) were significantly decreased only in the compliant group. The change in body mass index and dual-echo fat fraction showed a positive correlation (ρ = 0.418, P = 0.030). CONCLUSION: Hepatic fat quantification MR can be a non-invasive, quantitative and useful tool for monitoring treatment effects in pediatric NASH. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 9741~9748 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipose Tissue/metabolism | - |
dc.subject.MESH | Adipose Tissue/pathology* | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Liver/pathology* | - |
dc.subject.MESH | Magnetic Resonance Imaging* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Medical Records | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/blood | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/pathology* | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/therapy* | - |
dc.subject.MESH | Patient Compliance | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Hepatic fat quantification magnetic resonance for monitoring treatment response in pediatric nonalcoholic steatohepatitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Hong Koh | - |
dc.contributor.googleauthor | Seung Kim | - |
dc.contributor.googleauthor | Myung-Joon Kim | - |
dc.contributor.googleauthor | Hyun Gi Kim | - |
dc.contributor.googleauthor | Hyun Joo Shin | - |
dc.contributor.googleauthor | Mi-Jung Lee | - |
dc.identifier.doi | 10.3748/wjg.v21.i33.9741 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02774 | - |
dc.contributor.localId | A00425 | - |
dc.contributor.localId | A00651 | - |
dc.contributor.localId | A01139 | - |
dc.contributor.localId | A02178 | - |
dc.contributor.localId | A00156 | - |
dc.relation.journalcode | J02795 | - |
dc.identifier.eissn | 2219-2840 | - |
dc.identifier.pmid | 26361421 | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Hepatic fat quantification magnetic resonance | - |
dc.subject.keyword | Monitoring | - |
dc.subject.keyword | Nonalcoholic fatty liver disease | - |
dc.subject.keyword | Steatohepatitis | - |
dc.contributor.alternativeName | Kim, Myung Joon | - |
dc.contributor.alternativeName | Kim, Seung | - |
dc.contributor.alternativeName | Kim, Hyun Gi | - |
dc.contributor.alternativeName | Shin, Hyun Joo | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Koh, Hong | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.contributor.affiliatedAuthor | Kim, Myung Joon | - |
dc.contributor.affiliatedAuthor | Kim, Seung | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Gi | - |
dc.contributor.affiliatedAuthor | Shin, Hyun Joo | - |
dc.contributor.affiliatedAuthor | Koh, Hong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 9741 | - |
dc.citation.endPage | 9748 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, Vol.21(33) : 9741-9748, 2015 | - |
dc.identifier.rimsid | 31412 | - |
dc.type.rims | ART | - |
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