0 300

Cited 8 times in

Intravitreal liposomal amphotericin B for treatment of endogenous candida endophthalmitis

Authors
 Jeong Hun Bae  ;  Sung Chul Lee 
Citation
 JAPANESE JOURNAL OF OPHTHALMOLOGY, Vol.59(5) : 346-352, 2015 
Journal Title
 JAPANESE JOURNAL OF OPHTHALMOLOGY 
ISSN
 0021-5155 
Issue Date
2015
MeSH
Aged ; Amphotericin B/therapeutic use* ; Antifungal Agents/therapeutic use* ; Candida albicans/isolation & purification ; Candidiasis/diagnosis ; Candidiasis/drug therapy* ; Candidiasis/microbiology ; Combined Modality Therapy ; Endophthalmitis/diagnosis ; Endophthalmitis/drug therapy* ; Endophthalmitis/microbiology ; Eye Infections, Fungal/diagnosis ; Eye Infections, Fungal/drug therapy* ; Eye Infections, Fungal/microbiology ; Female ; Humans ; Intravitreal Injections ; Male ; Middle Aged ; Visual Acuity/physiology ; Vitrectomy ; Vitreous Body/microbiology
Keywords
AmBisome ; Candida endophthalmitis ; Intravitreal injection ; Liposomal amphotericin B ; Vitrectomy
Abstract
PURPOSE: To evaluate the outcomes of intravitreal liposomal amphotericin B (L-AmB) for treatment of endogenous candida endophthalmitis. METHODS: Medical records of four patients with endogenous candida endophthalmitis treated with intravitreal L-AmB injection alone or combined with vitrectomy were reviewed. RESULTS: Endogenous candida endophthalmitis developed in two patients after gastrointestinal surgery, in one patient with sepsis, and in one patient undergoing systemic chemotherapy for metastatic breast cancer. Three eyes of two patients exhibited toxic uveitis following repetitive intravitreal injection of amphotericin B deoxycholate (AmB-D, 10 μg/0.1 ml). The other patients had general health issues that restricted the use of AmB-D due to the potential risk of systemic toxicity. Seven eyes underwent intravitreal injection of L-AmB (10 μg/0.1 ml) with or without vitrectomy. In these patients, intraocular inflammation and vitreous opacities resolved, and chorioretinal infiltrates evolved into fibrotic scars. Visual acuity improved and stabilized in all eyes during the follow-up period. CONCLUSIONS: Intravitreal L-AmB seems to be well tolerated and effective in the treatment of endogenous candida endophthalmitis, and may be a reasonable alternative for patients who cannot endure the side effects or toxicity associated with conventional AmB-D therapy.
Full Text
http://link.springer.com/article/10.1007%2Fs10384-015-0397-x
DOI
10.1007/s10384-015-0397-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141190
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links