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Plasma periostin associates significantly with non-vertebral but not vertebral fractures in postmenopausal women: Clinical evidence for the different effects of periostin depending on the skeletal site

 Beom-Jun Kim  ;  Yumie Rhee  ;  Chong Hwa Kim  ;  Ki Hyun Baek  ;  Yong-Ki Mine  ;  Deog-Yoon Kim  ;  Seong Hee Ahn  ;  Hyeonmok Kim  ;  Seung Hun Lee  ;  Sun-Young Lee  ;  Moo-Il Kang  ;  Jung-Min Koh 
 BONE, Vol.81 : 435-441, 2015 
Journal Title
Issue Date
Absorptiometry, Photon ; Aged ; Bone Density ; Bone and Bones/drug effects* ; Case-Control Studies ; Cell Adhesion Molecules/blood* ; Female ; Femur/diagnostic imaging ; Femur/physiology ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Middle Aged ; Osteoporosis, Postmenopausal/prevention & control ; Osteoporotic Fractures/blood ; Osteoporotic Fractures/diagnostic imaging ; Osteoporotic Fractures/prevention & control* ; Postmenopause ; Risk Factors ; Spinal Fractures/blood ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/prevention & control*
Bone mineral density ; Non-vertebral fracture ; Osteoporotic fracture ; Periostin ; Postmenopausal women
BACKGROUND: Periostin is preferentially expressed by the periosteum, which mainly covers the long bones. Therefore, the role of periostin in osteoporotic fracture (OF) may differ depending on bone type. We performed a case-control study to investigate whether periostin can serve as a predictor of OF risk, particularly after dividing OFs into non-vertebral and vertebral fractures. METHODS: Among 532 consecutive postmenopausal women not taking any drug or without any disease that could affect bone metabolism, 133 cases with OF (i.e., non-vertebral and/or vertebral fractures) and 133 age- and body mass index-matched controls were enrolled. Non-vertebral (i.e., forearm, humerus, hip, and pelvis; n=81) and morphological vertebral (n=62) fractures were identified by an interviewer-assisted questionnaire and lateral thoracolumbar radiographs, respectively. Bone mineral density (BMD) and plasma periostin levels were also measured. RESULTS: Plasma periostin was markedly higher in subjects with non-vertebral fracture than their controls even after adjustment for BMD and potential confounders (P=0.006). Each standard deviation increment of plasma periostin was associated with a multivariable-adjusted odds ratio of 1.59 for non-vertebral fracture. The odds for non-vertebral fracture were 2.48-fold higher in subjects in the highest periostin tertile compared with those in the lowest periostin tertile (95% confidence interval=1.10-5.61). However, associations between plasma periostin and vertebral fracture were not observed, regardless of the adjustment model used. Consistently, plasma periostin levels were inversely associated with proximal femur BMD (P=0.007 to 0.030) but not lumbar spine BMD. In subgroup analyses, plasma periostin had no correlation with the levels of classical bone turnover markers. CONCLUSIONS: Plasma periostin may be a potential biomarker of the risk of OF, especially in non-spinal skeletal sites, such as the limbs, rather than spine.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
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