Cited 42 times in
Plasma periostin associates significantly with non-vertebral but not vertebral fractures in postmenopausal women: Clinical evidence for the different effects of periostin depending on the skeletal site
DC Field | Value | Language |
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dc.contributor.author | 이유미 | - |
dc.date.accessioned | 2016-02-04T11:45:09Z | - |
dc.date.available | 2016-02-04T11:45:09Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 8756-3282 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141121 | - |
dc.description.abstract | BACKGROUND: Periostin is preferentially expressed by the periosteum, which mainly covers the long bones. Therefore, the role of periostin in osteoporotic fracture (OF) may differ depending on bone type. We performed a case-control study to investigate whether periostin can serve as a predictor of OF risk, particularly after dividing OFs into non-vertebral and vertebral fractures. METHODS: Among 532 consecutive postmenopausal women not taking any drug or without any disease that could affect bone metabolism, 133 cases with OF (i.e., non-vertebral and/or vertebral fractures) and 133 age- and body mass index-matched controls were enrolled. Non-vertebral (i.e., forearm, humerus, hip, and pelvis; n=81) and morphological vertebral (n=62) fractures were identified by an interviewer-assisted questionnaire and lateral thoracolumbar radiographs, respectively. Bone mineral density (BMD) and plasma periostin levels were also measured. RESULTS: Plasma periostin was markedly higher in subjects with non-vertebral fracture than their controls even after adjustment for BMD and potential confounders (P=0.006). Each standard deviation increment of plasma periostin was associated with a multivariable-adjusted odds ratio of 1.59 for non-vertebral fracture. The odds for non-vertebral fracture were 2.48-fold higher in subjects in the highest periostin tertile compared with those in the lowest periostin tertile (95% confidence interval=1.10-5.61). However, associations between plasma periostin and vertebral fracture were not observed, regardless of the adjustment model used. Consistently, plasma periostin levels were inversely associated with proximal femur BMD (P=0.007 to 0.030) but not lumbar spine BMD. In subgroup analyses, plasma periostin had no correlation with the levels of classical bone turnover markers. CONCLUSIONS: Plasma periostin may be a potential biomarker of the risk of OF, especially in non-spinal skeletal sites, such as the limbs, rather than spine. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 435~441 | - |
dc.relation.isPartOf | BONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorptiometry, Photon | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bone Density | - |
dc.subject.MESH | Bone and Bones/drug effects* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cell Adhesion Molecules/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Femur/diagnostic imaging | - |
dc.subject.MESH | Femur/physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lumbar Vertebrae/diagnostic imaging | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Osteoporosis, Postmenopausal/prevention & control | - |
dc.subject.MESH | Osteoporotic Fractures/blood | - |
dc.subject.MESH | Osteoporotic Fractures/diagnostic imaging | - |
dc.subject.MESH | Osteoporotic Fractures/prevention & control* | - |
dc.subject.MESH | Postmenopause | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Spinal Fractures/blood | - |
dc.subject.MESH | Spinal Fractures/diagnostic imaging | - |
dc.subject.MESH | Spinal Fractures/prevention & control* | - |
dc.title | Plasma periostin associates significantly with non-vertebral but not vertebral fractures in postmenopausal women: Clinical evidence for the different effects of periostin depending on the skeletal site | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Beom-Jun Kim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Chong Hwa Kim | - |
dc.contributor.googleauthor | Ki Hyun Baek | - |
dc.contributor.googleauthor | Yong-Ki Mine | - |
dc.contributor.googleauthor | Deog-Yoon Kim | - |
dc.contributor.googleauthor | Seong Hee Ahn | - |
dc.contributor.googleauthor | Hyeonmok Kim | - |
dc.contributor.googleauthor | Seung Hun Lee | - |
dc.contributor.googleauthor | Sun-Young Lee | - |
dc.contributor.googleauthor | Moo-Il Kang | - |
dc.contributor.googleauthor | Jung-Min Koh | - |
dc.identifier.doi | 10.1016/j.bone.2015.08.014 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03012 | - |
dc.relation.journalcode | J00381 | - |
dc.identifier.eissn | 1873-2763 | - |
dc.identifier.pmid | 26297442 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S8756328215003257 | - |
dc.subject.keyword | Bone mineral density | - |
dc.subject.keyword | Non-vertebral fracture | - |
dc.subject.keyword | Osteoporotic fracture | - |
dc.subject.keyword | Periostin | - |
dc.subject.keyword | Postmenopausal women | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 81 | - |
dc.citation.startPage | 435 | - |
dc.citation.endPage | 441 | - |
dc.identifier.bibliographicCitation | BONE, Vol.81 : 435-441, 2015 | - |
dc.identifier.rimsid | 30525 | - |
dc.type.rims | ART | - |
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