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Plasma periostin associates significantly with non-vertebral but not vertebral fractures in postmenopausal women: Clinical evidence for the different effects of periostin depending on the skeletal site

DC FieldValueLanguage
dc.contributor.author이유미-
dc.date.accessioned2016-02-04T11:45:09Z-
dc.date.available2016-02-04T11:45:09Z-
dc.date.issued2015-
dc.identifier.issn8756-3282-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141121-
dc.description.abstractBACKGROUND: Periostin is preferentially expressed by the periosteum, which mainly covers the long bones. Therefore, the role of periostin in osteoporotic fracture (OF) may differ depending on bone type. We performed a case-control study to investigate whether periostin can serve as a predictor of OF risk, particularly after dividing OFs into non-vertebral and vertebral fractures. METHODS: Among 532 consecutive postmenopausal women not taking any drug or without any disease that could affect bone metabolism, 133 cases with OF (i.e., non-vertebral and/or vertebral fractures) and 133 age- and body mass index-matched controls were enrolled. Non-vertebral (i.e., forearm, humerus, hip, and pelvis; n=81) and morphological vertebral (n=62) fractures were identified by an interviewer-assisted questionnaire and lateral thoracolumbar radiographs, respectively. Bone mineral density (BMD) and plasma periostin levels were also measured. RESULTS: Plasma periostin was markedly higher in subjects with non-vertebral fracture than their controls even after adjustment for BMD and potential confounders (P=0.006). Each standard deviation increment of plasma periostin was associated with a multivariable-adjusted odds ratio of 1.59 for non-vertebral fracture. The odds for non-vertebral fracture were 2.48-fold higher in subjects in the highest periostin tertile compared with those in the lowest periostin tertile (95% confidence interval=1.10-5.61). However, associations between plasma periostin and vertebral fracture were not observed, regardless of the adjustment model used. Consistently, plasma periostin levels were inversely associated with proximal femur BMD (P=0.007 to 0.030) but not lumbar spine BMD. In subgroup analyses, plasma periostin had no correlation with the levels of classical bone turnover markers. CONCLUSIONS: Plasma periostin may be a potential biomarker of the risk of OF, especially in non-spinal skeletal sites, such as the limbs, rather than spine.-
dc.description.statementOfResponsibilityopen-
dc.format.extent435~441-
dc.relation.isPartOfBONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbsorptiometry, Photon-
dc.subject.MESHAged-
dc.subject.MESHBone Density-
dc.subject.MESHBone and Bones/drug effects*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCell Adhesion Molecules/blood*-
dc.subject.MESHFemale-
dc.subject.MESHFemur/diagnostic imaging-
dc.subject.MESHFemur/physiology-
dc.subject.MESHHumans-
dc.subject.MESHLumbar Vertebrae/diagnostic imaging-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsteoporosis, Postmenopausal/prevention & control-
dc.subject.MESHOsteoporotic Fractures/blood-
dc.subject.MESHOsteoporotic Fractures/diagnostic imaging-
dc.subject.MESHOsteoporotic Fractures/prevention & control*-
dc.subject.MESHPostmenopause-
dc.subject.MESHRisk Factors-
dc.subject.MESHSpinal Fractures/blood-
dc.subject.MESHSpinal Fractures/diagnostic imaging-
dc.subject.MESHSpinal Fractures/prevention & control*-
dc.titlePlasma periostin associates significantly with non-vertebral but not vertebral fractures in postmenopausal women: Clinical evidence for the different effects of periostin depending on the skeletal site-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorBeom-Jun Kim-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorChong Hwa Kim-
dc.contributor.googleauthorKi Hyun Baek-
dc.contributor.googleauthorYong-Ki Mine-
dc.contributor.googleauthorDeog-Yoon Kim-
dc.contributor.googleauthorSeong Hee Ahn-
dc.contributor.googleauthorHyeonmok Kim-
dc.contributor.googleauthorSeung Hun Lee-
dc.contributor.googleauthorSun-Young Lee-
dc.contributor.googleauthorMoo-Il Kang-
dc.contributor.googleauthorJung-Min Koh-
dc.identifier.doi10.1016/j.bone.2015.08.014-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03012-
dc.relation.journalcodeJ00381-
dc.identifier.eissn1873-2763-
dc.identifier.pmid26297442-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S8756328215003257-
dc.subject.keywordBone mineral density-
dc.subject.keywordNon-vertebral fracture-
dc.subject.keywordOsteoporotic fracture-
dc.subject.keywordPeriostin-
dc.subject.keywordPostmenopausal women-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.rights.accessRightsnot free-
dc.citation.volume81-
dc.citation.startPage435-
dc.citation.endPage441-
dc.identifier.bibliographicCitationBONE, Vol.81 : 435-441, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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