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The Effect of Polydeoxyribonucleotide on Ischemic Rat Skin Flap Survival

Authors
 Lee, Dong Won  ;  Hong, Hyun Joon  ;  Roh, Huyn  ;  Lee, Won Jai 
Citation
 ANNALS OF PLASTIC SURGERY, Vol.75(1) : 84-90, 2015 
Journal Title
ANNALS OF PLASTIC SURGERY
ISSN
 0148-7043 
Issue Date
2015
MeSH
Animals ; Graft Survival/drug effects* ; Ischemia/drug therapy* ; Male ; Polydeoxyribonucleotides/pharmacology* ; Polydeoxyribonucleotides/therapeutic use* ; Rats ; Rats, Sprague-Dawley ; Skin Transplantation ; Surgical Flaps/blood supply*
Keywords
polydeoxyribonucleotide ; flap survival ; blood perfusion ; vascular endothelial growth factor
Abstract
Polydeoxyribonucleotide (PDRN) has multiple vascular actions such as angiogenesis and production of a vascular endothelial growth factor (VEGF) through the adenosine A2 receptor stimulation. We applied PDRN on the ischemic flap of rat back and investigated whether it enhances the skin flap survival. A total of 28 Sprague-Dawley rats were divided into 3 groups, namely, PDRN group, control group 1 (no treatment), and group 2 (phosphate-buffered saline injection). On the distally based flap of 3 × 9 cm in size, it was subdermally injected with PDRN or phosphate-buffered saline, which were administered 48 hours prior and immediately after flap elevation. The PDRN group was daily maintained by intraperitoneal administration of PDRN from the postoperative 1st day to 10th day. The mean survival rates of flap in PDRN group [79.5% (6.3%)] are significantly larger than control groups [1, 53.0% (6.9%); 2, 51.7% (6.7%)]. Serial measurements of blood perfusion also showed that the blood flux was significantly increased in almost part of the flap on the 10 days after PDRN injection. The number of CD31 positively stained vessels and expression of VEGF protein were significantly higher in the PDRN group. We propose that administration of PDRN into the ischemic skin flaps increased blood flux to the flap, VEGF expression, and number of capillaries, thereby improving the rat skin flap survival.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000637-201507000-00016&LSLINK=80&D=ovft
DOI
10.1097/SAP.0000000000000053
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Dong Won(이동원) ORCID logo https://orcid.org/0000-0003-0046-3139
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141089
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