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Evaluation with 3.0-T MR imaging: predicting the pathological response of triple-negative breast cancer treated with anthracycline and taxane neoadjuvant chemotherapy

DC FieldValueLanguage
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author김민정-
dc.contributor.author김승일-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.date.accessioned2016-02-04T11:39:41Z-
dc.date.available2016-02-04T11:39:41Z-
dc.date.issued2015-
dc.identifier.issn0284-1851-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140919-
dc.description.abstractBACKGROUND: Triple-negative breast cancer (TNBC) which expresses neither hormonal receptors nor HER-2 is associated with poor prognosis and shorter survival. Several studies have suggested that TNBC patients attaining pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) show a longer survival than those without pCR. PURPOSE: To assess the accuracy of 3.0-T breast magnetic resonance imaging (MRI) in predicting pCR and to evaluate the clinicoradiologic factors affecting the diagnostic accuracy of 3.0-T breast MRI in TNBC patients treated with anthracycline and taxane (ACD). MATERIAL AND METHODS: This retrospective study was approved by the institutional review board; patient consent was not required. Between 2009 and 2012, 35 TNBC patients with 3.0-T breast MRI prior to (n = 26) or after (n = 35) NAC were included. MRI findings were reviewed according to pCR to chemotherapy. The diagnostic accuracy of 3.0-T breast MRI for predicting pCR and the clinicoradiological factors affecting MRI accuracy and response to NAC were analyzed. RESULTS: 3.0-T MRI following NAC with ACD accurately predicted pCR in 91.4% of TNBC patients. The residual tumor size between pathology and 3.0-T MRI in non-pCR cases showed a higher correlation in the Ki-67-positive TNBC group (r = 0.947) than in the Ki-67 negative group (r = 0.375) with statistical trends (P = 0.069). Pre-treatment MRI in the non-pCR group compared to the pCR group showed a larger tumor size (P = 0.030) and non-mass presentation (P = 0.015). CONCLUSION: 3.0-T MRI in TNBC patients following NAC with ACD showed a high accuracy for predicting pCR to NAC. Ki-67 can affect the diagnostic accuracy of 3.0-T MRI for pCR to NAC with ACD in TNBC patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1069~1077-
dc.relation.isPartOfActa Radiologica-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEvaluation with 3.0-T MR imaging: predicting the pathological response of triple-negative breast cancer treated with anthracycline and taxane neoadjuvant chemotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorMin Jung Kim-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorSeung Kim Il-
dc.contributor.googleauthorByeong-Woo Park-
dc.identifier.doi10.1177/0284185114548507-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00473-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA00658-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.relation.journalcodeJ00033-
dc.identifier.urlhttp://acr.sagepub.com/content/56/9/1069.long-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNameKim, Min Jung-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.affiliatedAuthorKim, Min Jung-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthorKim, Seung Il-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.rights.accessRightsnot free-
dc.citation.volume56-
dc.citation.number9-
dc.citation.startPage1069-
dc.citation.endPage1077-
dc.identifier.bibliographicCitationActa Radiologica, Vol.56(9) : 1069-1077, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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