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Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis

 Sang Hoon Lee  ;  Moo Suk Park  ;  Byung Hoon Park  ;  Won Jai Jung  ;  In Seon Lee  ;  Song Yee Kim  ;  Eun Young Kim  ;  Ji Ye Jung  ;  Young Ae Kang  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Kyung Soo Chung 
 BioMed Research International, Vol.2015 : 789298-789298, 2015 
Journal Title
 BioMed Research International 
Issue Date
BACKGROUND: Despite extensive research and an improved standard of care, sepsis remains a disorder with a high mortality rate. Sepsis is accompanied by severe metabolic alterations. METHODS: We evaluated 117 patients with sepsis (severe sepsis [n = 19] and septic shock [n = 98]) who were admitted to the intensive care unit. Serum cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), free fatty acid (FFA), and apolipoprotein (Apo) A-I levels were measured on days 0, 1, 3, and 7. RESULTS: Nonsurvivors had low levels of cholesterol, TG, HDL, LDL, and Apo A-I on days 0, 1, 3, and 7. In a linear mixed model analysis, the variations in TG, LDL, FFA, and Apo A-I levels over time differed significantly between the groups (p = 0.043, p = 0.020, p = 0.005, and p = 0.015, resp.). According to multivariate analysis, TG levels and SOFA scores were associated with mortality on days 0 and 1 (p = 0.018 and p = 0.008, resp.). CONCLUSIONS: Our study illustrated that TG levels are associated with mortality in patients with sepsis. This may be attributable to alterations in serum lipid metabolism during sepsis, thus modulating the host response to inflammation in critically ill patients.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae) ; 김세규(Kim, Se Kyu) ; 김송이(Kim, Song Yee) ; 김영삼(Kim, Young Sam) ; 김은영(Kim, Eun Young) ; 박무석(Park, Moo Suk) ; 박병훈(Park, Byung Hoon) ; 이상훈(Lee, Sang Hoon) ; 이인선(Lee, In Sun) ; 장준(Chang, Joon) ; 정경수(Jung, Kyung Soo) ; 정원재(Jung, Won Jai) ; 정지예(Jung, Ji Ye)
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