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Comparative Study of Recombinant Human Bone Morphogenetic Protein-2 Carriers in Rat Subcutaneous Tissues: Pilot Study

Authors
 Sunkyu Lee  ;  Hyunmin Choi  ;  June-Sung Shim  ;  Moon-Kyu Chung  ;  Young-Bum Park 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.12(Suppl 2) : 138-146, 2015 
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
ISSN
 1738-2696 
Issue Date
2015
Keywords
Nanostructures, Calcium sulfate ; Bone morphogenetic protein 2 ; Osteogenesis ; Carrier
Abstract
The purpose of this study was to evaluate and compare the potential of using various biomaterials as a carrier of rhBMP-2 in the subcutaneous layer of rats. 5 subcutaneous defects were made in each of the dorsal surfaces of 10 rats. Then, the rats were divided into the following groups: Control group: sham-surgery control, Experimental group 1: rhBMP-2/Bio-Oss®, Experimental group 2: rhBMP-2/Collatape®, Experimental group 3: rhBMP-2/nCS. Histological and histometrical analysis were performed after the rats were sacrificed at 2 and 4 weeks. Regardless of the type of carrier, the groups treated with rhBMP-2 showed significantly greater bone formation when compared to the control group. The amount of new bone formation was greater at 4 week than 2 week. Total bone formation (%) at 4 week was the greatest in rhBMP/Bio-Oss® (26.76±10.13) group, followed by rhBMP/Collatape® (20.38±5.27) and rhBMP/nCS (4.34±2.58). Within the limitation of this study, the results showed that Bio-Oss®, Collatape®, nanocalcium sulfate all showed new bone formation when used as a carrier of rhBMP-2 in the subcutaneous layer of rats, indicating potential use as carriers for rhBMP-2.
Full Text
http://link.springer.com/article/10.1007%2Fs13770-015-0437-0
DOI
10.1007/s13770-015-0437-0
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Bum(박영범)
Shim, June Sung(심준성) ORCID logo https://orcid.org/0000-0003-1428-0122
Chung, Moon Kyu(정문규)
Choi, Hyun Min(최현민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140830
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