102 196

Cited 9 times in

Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting

 Min-Soo Kim  ;  Jeong-Rim Lee  ;  Eun-Mi Choi  ;  Eun Ho Kim  ;  Seung Ho Choi 
 YONSEI MEDICAL JOURNAL, Vol.56(5) : 1415-1420, 2015 
Journal Title
Issue Date
Adult ; Aged ; Anesthesia, General ; Antiemetics/administration & dosage ; Antiemetics/pharmacology* ; Cholecystectomy, Laparoscopic ; Female ; Genome, Human ; Genotype ; Humans ; Incidence ; Injections, Intravenous ; Male ; Middle Aged ; Ondansetron/administration & dosage ; Ondansetron/pharmacology* ; Polymorphism, Genetic ; Postoperative Nausea and Vomiting/chemically induced ; Postoperative Nausea and Vomiting/drug therapy* ; Postoperative Nausea and Vomiting/epidemiology ; Receptors, Serotonin, 5-HT3/drug effects* ; Receptors, Serotonin, 5-HT3/genetics* ; Time Factors
5-HT3 receptor ; Postoperative nausea and vomiting ; genetic polymorphism ; ondansetron
PURPOSE: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with ondansetron can experience PONV. In this study, we investigated whether the Y129S and -100_-102AAG deletion polymorphisms of the 5-HT3B receptor gene affect the efficacy of ondansetron in preventing PONV. MATERIALS AND METHODS: Two hundred and forty-five adult patients who underwent laparoscopic cholecystectomy were enrolled. Ondansetron 0.1 mg/kg was intravenously administered 30 minutes before the end of surgery. Genomic DNA was prepared from blood samples using a nucleic acid isolation device. Both the Y129S variant and the -100_-102AAG deletion variant were screened for using a single base primer extension assay and a DNA direct sequencing method, respectively. The relationship between genetic polymorphisms and clinical outcomes of ondansetron treatment was investigated. RESULTS: Among the 5-HT3B AAG deletion genotypes, the incidence of PONV was higher in patients with the homomutant than with other genotypes during the first 2 hours after surgery (p=0.02). There were no significant differences in the incidence of PONV among genotypes at 2-24 hours after surgery. In the Y129S variants of the 5-HT3B receptor gene, there were no significant differences in the incidence of PONV among genotypes during the first 2 hours and at 2-24 hours after surgery. CONCLUSION: The response to ondansetron for PONV was significantly influenced by the -100_-102AAG deletion polymorphisms of the 5-HT3B gene. Thus, the -100_-102AAG deletion variants may be a pharmacogenetic predictor for responsiveness to ondansetron for PONV.
Files in This Item:
T201502932.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Soo(김민수) ORCID logo https://orcid.org/0000-0001-8760-4568
Lee, Jeong Rim(이정림) ORCID logo https://orcid.org/0000-0002-7425-0462
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0001-8442-4406
Choi, Eun Kyeong(최은경)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.