Cited 20 times in
Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김민수 | - |
dc.contributor.author | 이정림 | - |
dc.contributor.author | 최승호 | - |
dc.contributor.author | 최은경 | - |
dc.date.accessioned | 2016-02-04T11:36:44Z | - |
dc.date.available | 2016-02-04T11:36:44Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140809 | - |
dc.description.abstract | PURPOSE: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with ondansetron can experience PONV. In this study, we investigated whether the Y129S and -100_-102AAG deletion polymorphisms of the 5-HT3B receptor gene affect the efficacy of ondansetron in preventing PONV. MATERIALS AND METHODS: Two hundred and forty-five adult patients who underwent laparoscopic cholecystectomy were enrolled. Ondansetron 0.1 mg/kg was intravenously administered 30 minutes before the end of surgery. Genomic DNA was prepared from blood samples using a nucleic acid isolation device. Both the Y129S variant and the -100_-102AAG deletion variant were screened for using a single base primer extension assay and a DNA direct sequencing method, respectively. The relationship between genetic polymorphisms and clinical outcomes of ondansetron treatment was investigated. RESULTS: Among the 5-HT3B AAG deletion genotypes, the incidence of PONV was higher in patients with the homomutant than with other genotypes during the first 2 hours after surgery (p=0.02). There were no significant differences in the incidence of PONV among genotypes at 2-24 hours after surgery. In the Y129S variants of the 5-HT3B receptor gene, there were no significant differences in the incidence of PONV among genotypes during the first 2 hours and at 2-24 hours after surgery. CONCLUSION: The response to ondansetron for PONV was significantly influenced by the -100_-102AAG deletion polymorphisms of the 5-HT3B gene. Thus, the -100_-102AAG deletion variants may be a pharmacogenetic predictor for responsiveness to ondansetron for PONV. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1415~1420 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anesthesia, General | - |
dc.subject.MESH | Antiemetics/administration & dosage | - |
dc.subject.MESH | Antiemetics/pharmacology* | - |
dc.subject.MESH | Cholecystectomy, Laparoscopic | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genome, Human | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Injections, Intravenous | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Ondansetron/administration & dosage | - |
dc.subject.MESH | Ondansetron/pharmacology* | - |
dc.subject.MESH | Polymorphism, Genetic | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/chemically induced | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/drug therapy* | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/epidemiology | - |
dc.subject.MESH | Receptors, Serotonin, 5-HT3/drug effects* | - |
dc.subject.MESH | Receptors, Serotonin, 5-HT3/genetics* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Min-Soo Kim | - |
dc.contributor.googleauthor | Jeong-Rim Lee | - |
dc.contributor.googleauthor | Eun-Mi Choi | - |
dc.contributor.googleauthor | Eun Ho Kim | - |
dc.contributor.googleauthor | Seung Ho Choi | - |
dc.identifier.doi | 10.3349/ymj.2015.56.5.1415 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03098 | - |
dc.contributor.localId | A04146 | - |
dc.contributor.localId | A04101 | - |
dc.contributor.localId | A00463 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 26256989 | - |
dc.subject.keyword | 5-HT3 receptor | - |
dc.subject.keyword | Postoperative nausea and vomiting | - |
dc.subject.keyword | genetic polymorphism | - |
dc.subject.keyword | ondansetron | - |
dc.contributor.alternativeName | Kim, Min Soo | - |
dc.contributor.alternativeName | Lee, Jeong Rim | - |
dc.contributor.alternativeName | Choi, Seung Ho | - |
dc.contributor.alternativeName | Choi, Eun Kyeong | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Rim | - |
dc.contributor.affiliatedAuthor | Choi, Eun Kyeong | - |
dc.contributor.affiliatedAuthor | Choi, Seung Ho | - |
dc.contributor.affiliatedAuthor | Kim, Min Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 56 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1415 | - |
dc.citation.endPage | 1420 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.56(5) : 1415-1420, 2015 | - |
dc.identifier.rimsid | 30322 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.