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Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting

DC FieldValueLanguage
dc.contributor.author김민수-
dc.contributor.author이정림-
dc.contributor.author최승호-
dc.contributor.author최은경-
dc.date.accessioned2016-02-04T11:36:44Z-
dc.date.available2016-02-04T11:36:44Z-
dc.date.issued2015-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140809-
dc.description.abstractPURPOSE: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with ondansetron can experience PONV. In this study, we investigated whether the Y129S and -100_-102AAG deletion polymorphisms of the 5-HT3B receptor gene affect the efficacy of ondansetron in preventing PONV. MATERIALS AND METHODS: Two hundred and forty-five adult patients who underwent laparoscopic cholecystectomy were enrolled. Ondansetron 0.1 mg/kg was intravenously administered 30 minutes before the end of surgery. Genomic DNA was prepared from blood samples using a nucleic acid isolation device. Both the Y129S variant and the -100_-102AAG deletion variant were screened for using a single base primer extension assay and a DNA direct sequencing method, respectively. The relationship between genetic polymorphisms and clinical outcomes of ondansetron treatment was investigated. RESULTS: Among the 5-HT3B AAG deletion genotypes, the incidence of PONV was higher in patients with the homomutant than with other genotypes during the first 2 hours after surgery (p=0.02). There were no significant differences in the incidence of PONV among genotypes at 2-24 hours after surgery. In the Y129S variants of the 5-HT3B receptor gene, there were no significant differences in the incidence of PONV among genotypes during the first 2 hours and at 2-24 hours after surgery. CONCLUSION: The response to ondansetron for PONV was significantly influenced by the -100_-102AAG deletion polymorphisms of the 5-HT3B gene. Thus, the -100_-102AAG deletion variants may be a pharmacogenetic predictor for responsiveness to ondansetron for PONV.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1415~1420-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnesthesia, General-
dc.subject.MESHAntiemetics/administration & dosage-
dc.subject.MESHAntiemetics/pharmacology*-
dc.subject.MESHCholecystectomy, Laparoscopic-
dc.subject.MESHFemale-
dc.subject.MESHGenome, Human-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHInjections, Intravenous-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOndansetron/administration & dosage-
dc.subject.MESHOndansetron/pharmacology*-
dc.subject.MESHPolymorphism, Genetic-
dc.subject.MESHPostoperative Nausea and Vomiting/chemically induced-
dc.subject.MESHPostoperative Nausea and Vomiting/drug therapy*-
dc.subject.MESHPostoperative Nausea and Vomiting/epidemiology-
dc.subject.MESHReceptors, Serotonin, 5-HT3/drug effects*-
dc.subject.MESHReceptors, Serotonin, 5-HT3/genetics*-
dc.subject.MESHTime Factors-
dc.titleAssociation of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorMin-Soo Kim-
dc.contributor.googleauthorJeong-Rim Lee-
dc.contributor.googleauthorEun-Mi Choi-
dc.contributor.googleauthorEun Ho Kim-
dc.contributor.googleauthorSeung Ho Choi-
dc.identifier.doi10.3349/ymj.2015.56.5.1415-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03098-
dc.contributor.localIdA04146-
dc.contributor.localIdA04101-
dc.contributor.localIdA00463-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid26256989-
dc.subject.keyword5-HT3 receptor-
dc.subject.keywordPostoperative nausea and vomiting-
dc.subject.keywordgenetic polymorphism-
dc.subject.keywordondansetron-
dc.contributor.alternativeNameKim, Min Soo-
dc.contributor.alternativeNameLee, Jeong Rim-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameChoi, Eun Kyeong-
dc.contributor.affiliatedAuthorLee, Jeong Rim-
dc.contributor.affiliatedAuthorChoi, Eun Kyeong-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorKim, Min Soo-
dc.rights.accessRightsfree-
dc.citation.volume56-
dc.citation.number5-
dc.citation.startPage1415-
dc.citation.endPage1420-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.56(5) : 1415-1420, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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