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Methotrexate-induced Oral Mucositis

 Hye Jin Lee  ;  Jeong Seung Kwon  ;  Young Chan Choi  ;  Hyung Joon Ahn 
 Journal of Oral Medicine and Pain, Vol.40(2) : 82-87, 2015 
Journal Title
 Journal of Oral Medicine and Pain 
Issue Date
Folic acid deficiency ; Methotrexate ; Oral mucositis ; Rheumatoid arthritis
Methotrexate (MTX) is a chemotherapeutic agent that is used to treat a host of malignancies. But recently, MTX has also been used as a therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, and systemic lupus erythematosus. However, MTX is an antimetabolite that affects rapidly dividing normal cells such as oral mucosal epithelial cells, gastrointestinal epithelial cells, and bone marrow cells?which explains why oral mucositis is often an initial manifestation of MTX toxicity. Because oral lesions are frequently initially presented in dental clinics, dentists should consider the possibility of adverse drug reactions in the differential diagnoses of oral lesions through a meticulous collection of patients’ medical histories. In this report, we examine patients who suffered from oral ulcerative lesions upon diagnosis of MTX-induced oral mucositis. Then, we suggest approaches for the diagnosis and treatment of MTX-induced oral mucositis through a review of literature.
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2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jeong Seung(권정승) ORCID logo https://orcid.org/0000-0003-4584-7355
Ahn, Hyoung Joon(안형준)
Choi, Young Chan(최영찬)
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