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Methotrexate-induced Oral Mucositis

Authors
 Hye Jin Lee  ;  Jeong Seung Kwon  ;  Young Chan Choi  ;  Hyung Joon Ahn 
Citation
 Journal of Oral Medicine and Pain, Vol.40(2) : 82-87, 2015 
Journal Title
 Journal of Oral Medicine and Pain 
ISSN
 2288-9272 
Issue Date
2015
Abstract
Methotrexate (MTX) is a chemotherapeutic agent that is used to treat a host of malignancies. But recently, MTX has also been used as a therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, and systemic lupus erythematosus. However, MTX is an antimetabolite that affects rapidly dividing normal cells such as oral mucosal epithelial cells, gastrointestinal epithelial cells, and bone marrow cells?which explains why oral mucositis is often an initial manifestation of MTX toxicity. Because oral lesions are frequently initially presented in dental clinics, dentists should consider the possibility of adverse drug reactions in the differential diagnoses of oral lesions through a meticulous collection of patients’ medical histories. In this report, we examine patients who suffered from oral ulcerative lesions upon diagnosis of MTX-induced oral mucositis. Then, we suggest approaches for the diagnosis and treatment of MTX-induced oral mucositis through a review of literature.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140745
DOI
10.14476/jomp.2015.40.2.82
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실)
Yonsei Authors
권정승(Kwon, Jeong Seung) ; 안형준(Ahn, Hyoung Joon) ; 최영찬(Choi, Young Chan)
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