614 375

Cited 0 times in

Methotrexate-induced Oral Mucositis

Authors
 Hye Jin Lee  ;  Jeong Seung Kwon  ;  Young Chan Choi  ;  Hyung Joon Ahn 
Citation
 Journal of Oral Medicine and Pain, Vol.40(2) : 82-87, 2015 
Journal Title
 Journal of Oral Medicine and Pain 
ISSN
 2288-9272 
Issue Date
2015
Keywords
Folic acid deficiency ; Methotrexate ; Oral mucositis ; Rheumatoid arthritis
Abstract
Methotrexate (MTX) is a chemotherapeutic agent that is used to treat a host of malignancies. But recently, MTX has also been used as a therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, and systemic lupus erythematosus. However, MTX is an antimetabolite that affects rapidly dividing normal cells such as oral mucosal epithelial cells, gastrointestinal epithelial cells, and bone marrow cells?which explains why oral mucositis is often an initial manifestation of MTX toxicity. Because oral lesions are frequently initially presented in dental clinics, dentists should consider the possibility of adverse drug reactions in the differential diagnoses of oral lesions through a meticulous collection of patients’ medical histories. In this report, we examine patients who suffered from oral ulcerative lesions upon diagnosis of MTX-induced oral mucositis. Then, we suggest approaches for the diagnosis and treatment of MTX-induced oral mucositis through a review of literature.
Files in This Item:
T201502792.pdf Download
DOI
10.14476/jomp.2015.40.2.82
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jeong Seung(권정승) ORCID logo https://orcid.org/0000-0003-4584-7355
Ahn, Hyoung Joon(안형준)
Choi, Young Chan(최영찬)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140745
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse