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In vitro activity of tedizolid against gram-positive bacteria in patients with skin and skin structure infections and hospital-acquired pneumonia: a Korean multicenter study

Authors
 Yangsoon Lee ; Sung Kuk Hong ; Kyungwon Lee ; Dongeun Yong ; Weonbin Im ; SungHak Choi 
Citation
 Annals of Laboratory Medicine, Vol.35(5) : 523~530, 2015 
Journal Title
 Annals of Laboratory Medicine 
ISSN
 2234-3806 
Issue Date
2015
Abstract
We compared the activities of tedizolid to those of linezolid and other commonly used antimicrobial agents against gram-positive cocci recovered from patients with skin and skin structure infections (SSSIs) and hospital-acquired pneumonia (HAP) in Korean hospitals. Gram-positive isolates were collected from 356 patients with SSSIs and 144 patients with HAP at eight hospitals in Korea from 2011 to 2014. SSSIs included impetigo, cellulitis, erysipelas, furuncles, abscesses, and infected burns. Antimicrobial susceptibility was tested by using the CLSI agar dilution method. All of the gram-positive isolates were inhibited by ≤1 μg/mL tedizolid. The minimum inhibitory concentration [MIC]₉₀ of tedizolid was 0.5 μg/mL for methicillin-resistant Staphylococcus aureus, which was 4-fold lower than that of linezolid. Tedizolid may become a useful option for the treatment of SSSIs and HAP caused by gram-positive bacteria.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140720
DOI
10.3343/alm.2015.35.5.523
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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