139 217

Cited 13 times in

In vitro activity of tedizolid against gram-positive bacteria in patients with skin and skin structure infections and hospital-acquired pneumonia: a Korean multicenter study

Authors
 Yangsoon Lee  ;  Sung Kuk Hong  ;  SungHak Choi  ;  Weonbin Im  ;  Dongeun Yong  ;  Kyungwon Lee 
Citation
 ANNALS OF LABORATORY MEDICINE, Vol.35(5) : 523-530, 2015 
Journal Title
 ANNALS OF LABORATORY MEDICINE 
ISSN
 2234-3806 
Issue Date
2015
MeSH
Anti-Bacterial Agents/pharmacology* ; Asian Continental Ancestry Group ; Gram-Positive Bacteria/drug effects* ; Gram-Positive Bacteria/isolation & purification ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/microbiology ; Hospitals ; Humans ; Linezolid/pharmacology ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Organophosphates/pharmacology* ; Oxazoles/pharmacology* ; Pneumonia/diagnosis ; Pneumonia/microbiology* ; Republic of Korea ; Skin/microbiology* ; Skin Diseases/diagnosis ; Skin Diseases/microbiology*
Keywords
Gram-positive bacteria ; Infection ; Pneumonia ; Skin ; Soft tissue ; Tedizolid
Abstract
We compared the activities of tedizolid to those of linezolid and other commonly used antimicrobial agents against gram-positive cocci recovered from patients with skin and skin structure infections (SSSIs) and hospital-acquired pneumonia (HAP) in Korean hospitals. Gram-positive isolates were collected from 356 patients with SSSIs and 144 patients with HAP at eight hospitals in Korea from 2011 to 2014. SSSIs included impetigo, cellulitis, erysipelas, furuncles, abscesses, and infected burns. Antimicrobial susceptibility was tested by using the CLSI agar dilution method. All of the gram-positive isolates were inhibited by ≤1 μg/mL tedizolid. The minimum inhibitory concentration [MIC]₉₀ of tedizolid was 0.5 μg/mL for methicillin-resistant Staphylococcus aureus, which was 4-fold lower than that of linezolid. Tedizolid may become a useful option for the treatment of SSSIs and HAP caused by gram-positive bacteria.
Files in This Item:
T201502752.pdf Download
DOI
10.3343/alm.2015.35.5.523
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140720
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links