Cited 15 times in
The regulation of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase by autophagy in low-glycolytic hepatocellular carcinoma cells
DC Field | Value | Language |
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dc.contributor.author | 김경섭 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이향규 | - |
dc.contributor.author | 전정용 | - |
dc.contributor.author | 조병철 | - |
dc.date.accessioned | 2016-02-04T11:33:18Z | - |
dc.date.available | 2016-02-04T11:33:18Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140686 | - |
dc.description.abstract | The glycolytic phenotype is a dominant metabolic phenomenon in cancer and is reflected in becoming aggressive. Certain hepatocellular carcinoma lack increased glycolysis and prefer to uptake acetate than glucose for metabolism. Autophagy plays a role in preserving energies and nutrients when there is limited external nutrient supply and maintains glucose level of blood though supporting gluconeogenesis in the liver. As the role of autophagy and gluconeogenesis in HCC following the glycolic activity was not clear, we cultured HCC cells with different glycolytic levels in Hank's balanced salt solution (HBSS) to induce autophagy and conducted the activity of gluconeogenesis. Both autophagy and gluconeogenesis were induced in low glycolytic HCC cells (HepG2). In glycolytic Hep3B cells, only autophagy without gluconeogenesis was induced upon starvation. When autophagy was blocked, the level of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) was reduced in HepG2 cells and not in Hep3B. Altogether, we investigated contribution of hepatic gluconeogenesis to the metabolic phenotype of HCC cells and the role of autophagy as a potential mechanism regulating gluconeogenesis in low glycolytic HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 440~446 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Autophagy* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/enzymology | - |
dc.subject.MESH | Carcinoma, Hepatocellular/genetics | - |
dc.subject.MESH | Carcinoma, Hepatocellular/metabolism* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Gluconeogenesis* | - |
dc.subject.MESH | Glucose-6-Phosphatase/metabolism* | - |
dc.subject.MESH | Glycolysis* | - |
dc.subject.MESH | Hep G2 Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Liver/pathology | - |
dc.subject.MESH | Liver Neoplasms/enzymology | - |
dc.subject.MESH | Liver Neoplasms/genetics | - |
dc.subject.MESH | Liver Neoplasms/metabolism* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Phosphoenolpyruvate Carboxykinase (ATP)/metabolism* | - |
dc.subject.MESH | Starvation/genetics | - |
dc.subject.MESH | Starvation/metabolism | - |
dc.subject.MESH | Starvation/pathology | - |
dc.title | The regulation of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase by autophagy in low-glycolytic hepatocellular carcinoma cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학) | - |
dc.contributor.googleauthor | Jeong Yong Jeon | - |
dc.contributor.googleauthor | Hyangkyu Lee | - |
dc.contributor.googleauthor | Jeayeo Park | - |
dc.contributor.googleauthor | Misu Lee | - |
dc.contributor.googleauthor | Sae Whan Park | - |
dc.contributor.googleauthor | Ji Sook Kim | - |
dc.contributor.googleauthor | Milim Lee | - |
dc.contributor.googleauthor | Byoungchul Cho | - |
dc.contributor.googleauthor | Kyungsup Kim | - |
dc.contributor.googleauthor | Augustine M.K. Choi | - |
dc.contributor.googleauthor | Chun K. Kim | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.05.103 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00297 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A03282 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A03545 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 26036577 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X15300279 | - |
dc.subject.keyword | Autophagy | - |
dc.subject.keyword | Gluconeogenesis | - |
dc.subject.keyword | Glycolysis | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Starvation | - |
dc.contributor.alternativeName | Kim, Kyung Sup | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Lee, Hyang Kyu | - |
dc.contributor.alternativeName | Jeon, Jeong Yong | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sup | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Lee, Hyang Kyu | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Jeon, Jeong Yong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 463 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 440 | - |
dc.citation.endPage | 446 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.463(3) : 440-446, 2015 | - |
dc.identifier.rimsid | 30245 | - |
dc.type.rims | ART | - |
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