233 289

Cited 32 times in

Acute exposure to silica nanoparticles aggravate airway inflammation: different effects according to surface characteristics

DC FieldValueLanguage
dc.contributor.author박경희-
dc.contributor.author박중원-
dc.contributor.author박혜정-
dc.contributor.author손정호-
dc.contributor.author이재현-
dc.contributor.author최인홍-
dc.date.accessioned2016-02-04T11:33:09Z-
dc.date.available2016-02-04T11:33:09Z-
dc.date.issued2015-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140680-
dc.description.abstractSilica nanoparticles (SNPs) are widely used in many scientific and industrial fields despite the lack of proper evaluation of their potential toxicity. This study examined the effects of acute exposure to SNPs, either alone or in conjunction with ovalbumin (OVA), by studying the respiratory systems in exposed mouse models. Three types of SNPs were used: spherical SNPs (S-SNPs), mesoporous SNPs (M-SNPs), and PEGylated SNPs (P-SNPs). In the acute SNP exposure model performed, 6-week-old BALB/c female mice were intranasally inoculated with SNPs for 3 consecutive days. In the OVA/SNPs asthma model, the mice were sensitized two times via the peritoneal route with OVA. Additionally, the mice endured OVA with or without SNP challenges intranasally. Acute SNP exposure induced significant airway inflammation and airway hyper-responsiveness, particularly in the S-SNP group. In OVA/SNPs asthma models, OVA with SNP-treated group showed significant airway inflammation, more than those treated with only OVA and without SNPs. In these models, the P-SNP group induced lower levels of inflammation on airways than both the S-SNP or M-SNP groups. Interleukin (IL)-5, IL-13, IL-1β and interferon-γ levels correlated with airway inflammation in the tested models, without statistical significance. In the mouse models studied, increased airway inflammation was associated with acute SNPs exposure, whether exposed solely to SNPs or SNPs in conjunction with OVA. P-SNPs appear to be relatively safer for clinical use than S-SNPs and M-SNPs, as determined by lower observed toxicity and airway system inflammation.-
dc.description.statementOfResponsibilityopen-
dc.format.extente173-
dc.relation.isPartOfEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAsthma/chemically induced*-
dc.subject.MESHAsthma/pathology-
dc.subject.MESHFemale-
dc.subject.MESHInflammation/chemically induced*-
dc.subject.MESHInflammation/pathology-
dc.subject.MESHInterferon-gamma/analysis-
dc.subject.MESHInterleukins/analysis-
dc.subject.MESHLung/drug effects-
dc.subject.MESHLung/pathology*-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHNanoparticles/adverse effects*-
dc.subject.MESHNanoparticles/chemistry-
dc.subject.MESHOvalbumin/adverse effects-
dc.subject.MESHPolyethylene Glycols/adverse effects-
dc.subject.MESHPolyethylene Glycols/chemistry-
dc.subject.MESHSilicon Dioxide/adverse effects*-
dc.subject.MESHSilicon Dioxide/chemistry-
dc.subject.MESHSurface Properties-
dc.titleAcute exposure to silica nanoparticles aggravate airway inflammation: different effects according to surface characteristics-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorJung-Ho Sohn-
dc.contributor.googleauthorYoon-Ju Kim-
dc.contributor.googleauthorYoon Hee Park-
dc.contributor.googleauthorHeejae Han-
dc.contributor.googleauthorKyung Hee Park-
dc.contributor.googleauthorKangtaek Lee-
dc.contributor.googleauthorHoon Choi-
dc.contributor.googleauthorKiju Um-
dc.contributor.googleauthorIn-Hong Choi-
dc.contributor.googleauthorJung-Won Park-
dc.contributor.googleauthorJae-Hyun Lee-
dc.identifier.doi10.1038/emm.2015.50-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01427-
dc.contributor.localIdA01681-
dc.contributor.localIdA01769-
dc.contributor.localIdA01993-
dc.contributor.localIdA03086-
dc.contributor.localIdA04167-
dc.relation.journalcodeJ00860-
dc.identifier.eissn2092-6413-
dc.identifier.pmid26183169-
dc.contributor.alternativeNamePark, Kyung Hee-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNamePark, Hye Jung-
dc.contributor.alternativeNameSohn, Jung Ho-
dc.contributor.alternativeNameLee, Jae Hyun-
dc.contributor.alternativeNameChoi, In Hong-
dc.contributor.affiliatedAuthorPark, Kyung Hee-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.contributor.affiliatedAuthorPark, Hye Jung-
dc.contributor.affiliatedAuthorSohn, Jung Ho-
dc.contributor.affiliatedAuthorLee, Jae Hyun-
dc.contributor.affiliatedAuthorChoi, In Hong-
dc.rights.accessRightsfree-
dc.citation.volume47-
dc.citation.startPage173-
dc.identifier.bibliographicCitationEXPERIMENTAL AND MOLECULAR MEDICINE, Vol.47 : 173, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.