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mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress

Authors
 Sora Shin  ;  Obin Kwon  ;  Dong Goo Kim  ;  Chul Hoon Kim  ;  Jiwon Choi  ;  Sora Oh  ;  Somin Kwon  ;  Jee In Kang 
Citation
 Nature Neuroscience, Vol.18(7) : 1017-1024, 2015 
Journal Title
 Nature Neuroscience 
ISSN
 1097-6256 
Issue Date
2015
Abstract
Resilience to aversive events has a central role in determining whether stress leads to the development of depression. mGluR5 has been implicated in the pathophysiology of depression, but the effect of mGluR5 activity on stress resilience remains unexplored. We found that mGluR5(-/-) (also known as Grm5(-/-)) mice displayed more depression-like behaviors (for example, learned helplessness, social withdrawal and anhedonia) than control mice following exposure to various stressful stimuli. Lentiviral 'rescue' of mGluR5 in the nucleus accumbens (NAc) decreased these depression-like behaviors in mGluR5(-/-) mice. In the NAc, ΔFosB, whose induction promotes stress resilience, failed to be upregulated by stress in mGluR5(-/-) mice. Notably, targeted pharmacological activation of mGluR5 in the NAc increased ΔFosB expression. Our findings point to an essential role for mGluR5 in promoting stress resilience and suggest that a defect in mGluR5-mediated signaling in the NAc may represent an endophenotype for stress-induced depression.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140590
DOI
10.1038/nn.4028
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
강지인(Kang, Jee In) ; 권오빈(Kwon, O Bin) ; 김동구(Kim, Dong Goo) ; 김철훈(Kim, Chul Hoon) ; 신소라(Shin, So Ra) ; 오소라(Oh, So Ra)
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Full Text
http://www.nature.com/neuro/journal/v18/n7/full/nn.4028.html
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