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Epidemiology and Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa

Authors
 Duck Jin Hong  ;  Il Kwon Bae  ;  In-Ho Jang  ;  Seok Hoon Jeong  ;  Hyun-Kyung Kang  ;  Kyungwon Lee 
Citation
 INFECTION AND CHEMOTHERAPY, Vol.47(2) : 81-97, 2015 
Journal Title
 INFECTION AND CHEMOTHERAPY 
ISSN
 2093-2340 
Issue Date
2015
Keywords
Carbapenem ; Epidemiology ; Metallo-β-lactamase ; Multidrug resistance ; Pseudomonas aeruginosa
Abstract
Metallo-β-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all β-lactam antibiotics except monobactams. There are various types of metallo-β-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-β-lactamase (VIM), Sao Paulo metallo-β-lactamase (SPM), Germany imipenemase (GIM), New Delhi metallo-β-lactamase (NDM), Florence imipenemase (FIM). Each MBL gene is located on specific genetic elements including integrons, transposons, plasmids, or on the chromosome, in which they carry genes encoding determinants of resistance to carbapenems and other antibiotics, conferring multidrug resistance to P. aeruginosa. In addition, these genetic elements are transferable to other Gram-negative species, increasing the antimicrobial resistance rate and complicating the treatment of infected patients. Therefore, it is essential to understand the epidemiology, resistance mechanism, and molecular characteristics of MPPA for infection control and prevention of a possible global health crisis. Here, we highlight the characteristics of MPPA.
Files in This Item:
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DOI
10.3947/ic.2015.47.2.81
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Hong, Duck Jin(홍덕진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140565
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