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Lack of association between arterial stiffness and genetic variants by genome-wide association scan

Authors
 Sungha Park  ;  Ji-Young Lee  ;  Byeong-Keuk Kim  ;  Sang-Hak Lee  ;  Hyuk-Jae Chang  ;  DongHoon Choi  ;  Yangsoo Jang 
Citation
 Blood Pressure, Vol.24(4) : 258-261, 2015 
Journal Title
 Blood Pressure 
ISSN
 0803-7051 
Issue Date
2015
Abstract
BACKGROUND: Arterial stiffness is an independent predictor of cardiovascular disease risk. However, whether genetic risk variants are associated with arterial stiffness measures, such as pulse-wave velocity (PWV), is largely unknown. Therefore, we performed a genome-wide association study (GWAS) to identify single-nucleotide polymorphisms (SNPs) associated with PWV in a Korea population. METHOD: Study participants consisted of 402 patients in the Yonsei cardiovascular genome center cohort. Arterial stiffness was measured as brachial-ankle pulse-wave velocity (baPWV). Genotyping was performed in 402 subjects with the Axiom Genome-Wide ASI 1 Array Plate containing more than 600,000 SNP markers. The findings were tested for replication in independent subjects from a community-based cohort of 1206 individuals, using a Taqman assay to include two candidate SNPs. Associations with PWV were evaluated using an additive genetic model that included age, gender, systolic blood pressure and diastolic blood pressure as covariates. GWAS and replication analyses were conducted using the measured genotype method implemented in PLINK and SAS. RESULTS: We observed two candidate SNPs associated with baPWV in GWAS: rs7271920 (p = 7.15 × 10(-9)) and rs10125157 (p = 8.25 × 10(-7)). However, neither of these was significant in the replication cohort. CONCLUSION: In summary, we did not identify any common genetic variants associated with baPWV in cardiovascular patients.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140535
Full Text
http://www.tandfonline.com/doi/full/10.3109/08037051.2015.1049430
DOI
10.3109/08037051.2015.1049430
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김병극(Kim, Byeong Keuk)
박성하(Park, Sung Ha)
이상학(Lee, Sang Hak) ORCID logo https://orcid.org/0000-0002-4535-3745
이지영(Lee, Ji Young)
장양수(Jang, Yang Soo)
장혁재(Chang, Hyuck Jae)
최동훈(Choi, Dong Hoon)
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