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PSA-NCAM-negative neural crest cells emerging during neural induction of pluripotent stem cells cause mesodermal tumors and unwanted grafts

DC FieldValueLanguage
dc.contributor.author김동욱-
dc.contributor.author김한수-
dc.contributor.author박상현-
dc.contributor.author박철용-
dc.contributor.author유정은-
dc.contributor.author이동진-
dc.contributor.author이재석-
dc.contributor.author이준원-
dc.contributor.author지은현-
dc.contributor.author이준원-
dc.date.accessioned2016-02-04T11:26:37Z-
dc.date.available2016-02-04T11:26:37Z-
dc.date.issued2015-
dc.identifier.issn2213-6711-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140435-
dc.description.abstractTumorigenic potential of human pluripotent stem cells (hPSCs) is an important issue in clinical applications. Despite many efforts, PSC-derived neural precursor cells (NPCs) have repeatedly induced tumors in animal models even though pluripotent cells were not detected. We found that polysialic acid-neural cell adhesion molecule (PSA-NCAM)(-) cells among the early NPCs caused tumors, whereas PSA-NCAM(+) cells were nontumorigenic. Molecular profiling, global gene analysis, and multilineage differentiation of PSA-NCAM(-) cells confirm that they are multipotent neural crest stem cells (NCSCs) that could differentiate into both ectodermal and mesodermal lineages. Transplantation of PSA-NCAM(-) cells in a gradient manner mixed with PSA-NCAM(+) cells proportionally increased mesodermal tumor formation and unwanted grafts such as PERIPHERIN(+) cells or pigmented cells in the rat brain. Therefore, we suggest that NCSCs are a critical target for tumor prevention in hPSC-derived NPCs, and removal of PSA-NCAM(-) cells eliminates the tumorigenic potential originating from NCSCs after transplantation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfStem Cell Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePSA-NCAM-negative neural crest cells emerging during neural induction of pluripotent stem cells cause mesodermal tumors and unwanted grafts-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.contributor.googleauthorDongjin R. Lee-
dc.contributor.googleauthorJeong-Eun Yoo-
dc.contributor.googleauthorJae Souk Lee-
dc.contributor.googleauthorSanghyun Park-
dc.contributor.googleauthorJunwon Lee-
dc.contributor.googleauthorChul-Yong Park-
dc.contributor.googleauthorEunhyun Ji-
dc.contributor.googleauthorHan-Soo Kim-
dc.contributor.googleauthorDong-Youn Hwang-
dc.contributor.googleauthorDae-Sung Kim-
dc.contributor.googleauthorDong-Wook Kim-
dc.identifier.doi10.1016/j.stemcr.2015.04.002-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01100-
dc.contributor.localIdA01719-
dc.contributor.localIdA02734-
dc.contributor.localIdA03074-
dc.contributor.localIdA03179-
dc.contributor.localIdA03969-
dc.contributor.localIdA02505-
dc.contributor.localIdA01491-
dc.contributor.localIdA00406-
dc.relation.journalcodeJ02679-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S2213671115001022-
dc.contributor.alternativeNameKim, Dong Wook-
dc.contributor.alternativeNameKim, Han Soo-
dc.contributor.alternativeNamePark, Sang Hyun-
dc.contributor.alternativeNamePark, Chul Yong-
dc.contributor.alternativeNameYoo, Jeong Eun-
dc.contributor.alternativeNameLee, Dongjin R.-
dc.contributor.alternativeNameLee, Jae Souk-
dc.contributor.alternativeNameLee, Jun Won-
dc.contributor.alternativeNameJi, Eun Hyun-
dc.contributor.affiliatedAuthorKim, Han Soo-
dc.contributor.affiliatedAuthorPark, Chul Yong-
dc.contributor.affiliatedAuthorLee, Dongjin R.-
dc.contributor.affiliatedAuthorLee, Jae Souk-
dc.contributor.affiliatedAuthorLee, Jun Won-
dc.contributor.affiliatedAuthorJi, Eun Hyun-
dc.contributor.affiliatedAuthorYoo, Jeong Eun-
dc.contributor.affiliatedAuthorPark, Sang Hyun-
dc.contributor.affiliatedAuthorKim, Dong Wook-
dc.rights.accessRightsnot free-
dc.citation.volume4-
dc.citation.number5-
dc.citation.startPage821-
dc.citation.endPage834-
dc.identifier.bibliographicCitationStem Cell Reports, Vol.4(5) : 821-834, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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