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동일초점현미경을 이용한 비쇼그렌건성안 각막 미세구조의 변화 및 임상증상과의 관계

Other Titles
 Corneal Microstructural Changes in Non-Sj?gren Dry Eye Using Confocal Microscopy: Clinical Correlation 
 최은영  ;  김태임  ;  서경률  ;  김응권  ;  이형근 
 Journal of the Korean Ophthalmological Society, Vol.56(5) : 680-686, 2015 
Journal Title
 Journal of the Korean Ophthalmological Society (대한안과학회지) 
Issue Date
Confocal microscopy ; Dry eye ; In vivo confocal microscopy (IVCM) ; Non-Sjögren dry eye
Purpose: To investigate the relationship between changes of corneal epithelium and subbasal nerves in non-Sjögren dry eye using in vivo confocal microscope (IVCM) and self-reported clinical symptoms. Methods: The present study included 40 patients with dry eye and 18 healthy control subjects. The dry eye group underwent an evaluation of dry eye symptoms using visual analogue scale (VAS) score and was subdivided into 2 groups; score 0-5 as the low VAS score (LVS) group and score 6 - 10 as the high VAS score (HVS) group. The tear film break-up time, fluorescein staining, Schirmer test and microstructural imaging of epithelium, and subbasal nerve at cornea center with IVCM were performed on both eyes of each patient. Twenty-three normal eyes and 54 eyes of dry eye patients were included in the study. Cell densities and morphological characteristics were analyzed using ImageJ and NeuronJ softwares. Results: Both LVS and HVS groups had decreased cell density of superficial, intermediate, and basal epithelium (p < 0.001). Intermediate epithelial cells were more decreased in the dry eye group with more severe symptoms (p < 0.0001). Subbasal nerve density (p < 0.005) was more decreased and nerve beadings, tortuosity, and reflectivity increased in the HVS group than both LVS and control groups (p < 0.05). Conclusions: The alterations of corneal cellular level in dry eye patients visualized using IVCM are correlated with pathology and clinical symptoms and may be useful objective criteria in diagnosis and monitoring treatment efficacy.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
Choi, Eun Young(최은영) ORCID logo https://orcid.org/0000-0002-1668-6452
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