257 136

Cited 16 times in

Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures

Authors
 Seung-Tae Lee  ;  Marcus O. Muench  ;  Marina E. Fomin  ;  Jianqiao Xiao  ;  Mi Zhou  ;  Adam de Smith  ;  Jos´e I. Mart´ın-Subero  ;  Simon Heath  ;  E. Andres Houseman  ;  Ritu Roy  ;  Margaret Wrensch  ;  John Wiencke  ;  Catherine Metayer  ;  Joseph L. Wiemels 
Citation
 NUCLEIC ACIDS RESEARCH, Vol.43(5) : 2590-2602, 2015 
Journal Title
 NUCLEIC ACIDS RESEARCH 
ISSN
 0305-1048 
Issue Date
2015
MeSH
Alcohol Oxidoreductases/genetics ; B-Lymphocytes/metabolism* ; B-Lymphocytes/pathology ; Child ; CpG Islands/genetics ; DNA Methylation* ; Embryonic Stem Cells/metabolism* ; Epigenomics/methods* ; Gene Expression Profiling/methods* ; Histones/metabolism ; Humans ; Lysine/metabolism ; Methylation ; Nerve Tissue Proteins/genetics ; Oligonucleotide Array Sequence Analysis ; Polycomb Repressive Complex 2/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics* ; Precursor Cells, B-Lymphoid/metabolism ; Precursor Cells, B-Lymphoid/pathology ; Signal Transduction/genetics
Abstract
We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large inter-compartmental backbones. The deviations were exaggerated in lamina-associated domains, with differences corresponding to methylation clusters and/or cytogenetic groups. Our data also suggested a pivotal role of polycomb and CTBP2 in de novo methylation, which may be traced back to bivalency status of embryonic stem cells. Driven by these potent epigenetic modulations, suppression of polycomb target genes was observed along with disruption of developmental fate and cell cycle and mismatch repair pathways and altered activities of key upstream regulators.
Files in This Item:
T201501931.pdf Download
DOI
10.1093/nar/gkv103
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung-Tae(이승태) ORCID logo https://orcid.org/0000-0003-1047-1415
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140373
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse