Cited 38 times in
Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures
DC Field | Value | Language |
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dc.contributor.author | 이승태 | - |
dc.date.accessioned | 2016-02-04T11:24:56Z | - |
dc.date.available | 2016-02-04T11:24:56Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140373 | - |
dc.description.abstract | We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large inter-compartmental backbones. The deviations were exaggerated in lamina-associated domains, with differences corresponding to methylation clusters and/or cytogenetic groups. Our data also suggested a pivotal role of polycomb and CTBP2 in de novo methylation, which may be traced back to bivalency status of embryonic stem cells. Driven by these potent epigenetic modulations, suppression of polycomb target genes was observed along with disruption of developmental fate and cell cycle and mismatch repair pathways and altered activities of key upstream regulators. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | NUCLEIC ACIDS RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alcohol Oxidoreductases/genetics | - |
dc.subject.MESH | B-Lymphocytes/metabolism* | - |
dc.subject.MESH | B-Lymphocytes/pathology | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | CpG Islands/genetics | - |
dc.subject.MESH | DNA Methylation* | - |
dc.subject.MESH | Embryonic Stem Cells/metabolism* | - |
dc.subject.MESH | Epigenomics/methods* | - |
dc.subject.MESH | Gene Expression Profiling/methods* | - |
dc.subject.MESH | Histones/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lysine/metabolism | - |
dc.subject.MESH | Methylation | - |
dc.subject.MESH | Nerve Tissue Proteins/genetics | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Polycomb Repressive Complex 2/genetics | - |
dc.subject.MESH | Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics* | - |
dc.subject.MESH | Precursor Cells, B-Lymphoid/metabolism | - |
dc.subject.MESH | Precursor Cells, B-Lymphoid/pathology | - |
dc.subject.MESH | Signal Transduction/genetics | - |
dc.title | Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seung-Tae Lee | - |
dc.contributor.googleauthor | Marcus O. Muench | - |
dc.contributor.googleauthor | Marina E. Fomin | - |
dc.contributor.googleauthor | Jianqiao Xiao | - |
dc.contributor.googleauthor | Mi Zhou | - |
dc.contributor.googleauthor | Adam de Smith | - |
dc.contributor.googleauthor | Jos´e I. Mart´ın-Subero | - |
dc.contributor.googleauthor | Simon Heath | - |
dc.contributor.googleauthor | E. Andres Houseman | - |
dc.contributor.googleauthor | Ritu Roy | - |
dc.contributor.googleauthor | Margaret Wrensch | - |
dc.contributor.googleauthor | John Wiencke | - |
dc.contributor.googleauthor | Catherine Metayer | - |
dc.contributor.googleauthor | Joseph L. Wiemels | - |
dc.identifier.doi | 10.1093/nar/gkv103 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02930 | - |
dc.relation.journalcode | J02387 | - |
dc.identifier.eissn | 1362-4962 | - |
dc.identifier.pmid | 25690899 | - |
dc.contributor.alternativeName | Lee, Seung Tae | - |
dc.contributor.affiliatedAuthor | Lee, Seung Tae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 43 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2590 | - |
dc.citation.endPage | 2602 | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, Vol.43(5) : 2590-2602, 2015 | - |
dc.identifier.rimsid | 51588 | - |
dc.type.rims | ART | - |
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