Cited 32 times in
Impact of hyperthermia before and during ischemia-reperfusion on neuronal damage and gliosis in the gerbil hippocampus induced by transient cerebral ischemia
DC Field | Value | Language |
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dc.contributor.author | 김민정 | - |
dc.date.accessioned | 2016-02-04T11:24:16Z | - |
dc.date.available | 2016-02-04T11:24:16Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140349 | - |
dc.description.abstract | Hyperthermia can exacerbate the brain damage produced by ischemia. In the present study, we investigated the effects of hyperthermia before and during ischemia-reperfusion on neuronal damage and glial changes in the gerbil hippocampus following transient cerebral ischemia using cresyl violet staining, NeuN immunohistochemistry and Fluoro-Jade B histofluorescence staining. The animals were randomly assigned to 4 groups: (1) sham-operated animals with normothermia (normothermia + sham group); (2) ischemia-operated animals with normothermia (normothermia + ischemia group); (3) sham-operated animals with hyperthermia (hyperthermia + sham group); and (4) ischemia-operated animals with hyperthermia (hyperthermia + ischemia group). Hyperthermia (39.5 ± 0.2°C) was induced by exposing the gerbils to a heating pad connected to a rectal thermistor for 30 min before and during ischemia-reperfusion. In the normothermia+ischemia groups, a significant delayed neuronal death was observed in the stratum pyramidale (SP) of the hippocampal CA1 region (CA1) 5 days after ischemia-reperfusion. In the hyperthermia+ischemia groups, neuronal death in the SP of the CA1 occurred at 1 day post-ischemia, and neuronal death was observed in the SP of the CA2/3 region at 2 days post-ischemia. In addition, we examined activations of astrocytes and microglia using immunohistochemistry for anti-glial fibrillary acidic protein (GFAP) and anti-ionized calcium-binding adapter molecule 1 (Iba-1). GFAP-positive astrocytes and Iba-1-positive microglia in the ischemic hippocampus were activated much earlier and much more accelerated in the hyperthermia+ischemia groups than those in the normothermia+ischemia groups. Based on our findings, we suggest that an experimentally hyperthermic pre-condition before cerebral ischemic insult produces more extensive neuronal damage and glial activation in the ischemic hippocampus. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Death* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Fever/complications | - |
dc.subject.MESH | Fever/pathology* | - |
dc.subject.MESH | Gerbillinae | - |
dc.subject.MESH | Gliosis/etiology | - |
dc.subject.MESH | Gliosis/pathology* | - |
dc.subject.MESH | Hippocampus/pathology* | - |
dc.subject.MESH | Ischemic Attack, Transient/chemically induced | - |
dc.subject.MESH | Ischemic Attack, Transient/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Pyramidal Cells/pathology* | - |
dc.subject.MESH | Random Allocation | - |
dc.subject.MESH | Reperfusion Injury/chemically induced | - |
dc.subject.MESH | Reperfusion Injury/pathology* | - |
dc.title | Impact of hyperthermia before and during ischemia-reperfusion on neuronal damage and gliosis in the gerbil hippocampus induced by transient cerebral ischemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Min Joung Kim | - |
dc.contributor.googleauthor | Jun Hwi Cho | - |
dc.contributor.googleauthor | Jeong Hwi Cho | - |
dc.contributor.googleauthor | Joon Ha Park | - |
dc.contributor.googleauthor | Ji Hyeon Ahn | - |
dc.contributor.googleauthor | Hyun Jin Tae | - |
dc.contributor.googleauthor | Geum Sil Cho | - |
dc.contributor.googleauthor | Bing Chun Yan | - |
dc.contributor.googleauthor | In Koo Hwang | - |
dc.contributor.googleauthor | Choong Hyun Lee | - |
dc.contributor.googleauthor | Eun Joo Bae | - |
dc.contributor.googleauthor | Moo Ho Won | - |
dc.contributor.googleauthor | Jae Chul Lee | - |
dc.identifier.doi | 10.1016/j.jns.2014.11.015 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00473 | - |
dc.relation.journalcode | J01897 | - |
dc.identifier.eissn | 1878-5883 | - |
dc.identifier.pmid | 25434714 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022510X14007291 | - |
dc.subject.keyword | Delayed neuronal death | - |
dc.subject.keyword | Glial cells | - |
dc.subject.keyword | Hippocampal subregions | - |
dc.subject.keyword | Hyperthermic pre-condition | - |
dc.subject.keyword | Ischemia–reperfusion | - |
dc.subject.keyword | Pyramidal neurons | - |
dc.contributor.alternativeName | Kim, Min Jung | - |
dc.contributor.affiliatedAuthor | Kim, Min Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 348 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 110 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.348(1-2) : 101-110, 2015 | - |
dc.identifier.rimsid | 51572 | - |
dc.type.rims | ART | - |
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