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miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia

Authors
 Juhyun Song  ;  Yumi Oh  ;  Jong Eun Lee 
Citation
 EXPERIMENTAL NEUROBIOLOGY, Vol.24(2) : 117-125, 2015 
Journal Title
 EXPERIMENTAL NEUROBIOLOGY 
ISSN
 1226-2560 
Issue Date
2015
Keywords
ATG 3 ; Autophagy ; Beclin 1 ; Microglia ; Microtubule-associated protein light chain 3 (LC3) II ; microRNA-Let7A (miR-Let7A)
Abstract
Microglia regulate the secretion of various immunomediators in central nervous system diseases. Microglial autophagy is the crucial process for cell's survival and cytokine productions. Recent studies have reported that several microRNAs are involved in the autophagy system. miR-Let7A is such a microRNA that plays a role in various inflammation responses, and is magnified as a key modulator particularly in the autophagy system. In present study, we investigated whether miR-Let7A is involved in autophagy in activating microglia. Overexpression of miR-Let7A in LPS-stimulated BV2 microglial cells promoted the induction of the autophagy related factors such as LC3II, Beclin1, and ATG3. Our results suggest a potential role of miR-Let7A in the autophagy process of microglia during CNS inflammation.
Files in This Item:
T201501889.pdf Download
DOI
10.5607/en.2015.24.2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Song, Ju Hyun(송주현)
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140337
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