Cited 38 times in
Metabolism in embryonic and cancer stemness
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양재문 | - |
dc.contributor.author | 정재호 | - |
dc.date.accessioned | 2016-02-04T11:23:49Z | - |
dc.date.available | 2016-02-04T11:23:49Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140332 | - |
dc.description.abstract | Cells constantly adjust their metabolic state in response to extracellular signals and nutrient availability to meet their demand for energy and building blocks. Recently, there has been significant research into the metabolic aspects of embryonic stem cells/pluripotent stem cells (ESCs/PSCs) and cancer stem cells (CSCs), which has revealed the unique metabolic status of different stem cell lineages. While ESCs and CSCs were largely thought to harbor similar metabolic states, recent evidence demonstrates that their metabolic dependency is distinctly different. The glucose metabolism of ESCs largely depends on glycolysis, including a one-carbon pathway during differentiation. While proliferating cancer cells share the glycolytic phenotype of ESCs, the mitochondria-centric oxidative phosphorylation constitutes an important metabolic circuit of CSCs under metabolic stress, indicating the dynamic nature of metabolic plasticity. In this review, we catalogued metabolic signatures of cellular "stemness" to provide insights into the therapeutic potential of ESCs and CSCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 381~388 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Differentiation/physiology | - |
dc.subject.MESH | Cell Proliferation/physiology | - |
dc.subject.MESH | Embryonic Stem Cells/metabolism* | - |
dc.subject.MESH | Glucose/metabolism | - |
dc.subject.MESH | Glycolysis/physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mitochondria/metabolism | - |
dc.subject.MESH | Neoplasms/metabolism* | - |
dc.subject.MESH | Neoplastic Stem Cells/metabolism* | - |
dc.subject.MESH | Pluripotent Stem Cells/metabolism | - |
dc.subject.MESH | Stress, Physiological/physiology | - |
dc.title | Metabolism in embryonic and cancer stemness | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Hyonchol Jang | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Eugene Lee | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.identifier.doi | 10.1007/s12272-015-0558-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A03717 | - |
dc.relation.journalcode | J00229 | - |
dc.identifier.pmid | 25598509 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12272-015-0558-y | - |
dc.subject.keyword | Cancer metabolism | - |
dc.subject.keyword | Stem cell metabolism | - |
dc.subject.keyword | Cancer stem cell metabolism | - |
dc.subject.keyword | O-GlcNAc | - |
dc.subject.keyword | Oxidative phosphorylation | - |
dc.subject.keyword | Cancer stemness | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 38 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 381 | - |
dc.citation.endPage | 388 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, Vol.38(3) : 381-388, 2015 | - |
dc.identifier.rimsid | 51562 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.