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Glycated albumin and the risk of micro- and macrovascular complications in subjects with type 1 diabetes

 Hye-jin Yoon  ;  Yong-ho Lee  ;  So Ra Kim  ;  Tyler Hyungtaek Rim  ;  Eun Young Lee  ;  , Eun Seok Kang  ;  Bong-Soo Cha  ;  Hyun Chul Lee  ;  Byung-Wan Lee 
Journal Title
Issue Date
Adult ; Aged ; Carotid Intima-Media Thickness/trends ; Diabetes Mellitus, Type 1/blood* ; Diabetes Mellitus, Type 1/diagnosis* ; Diabetes Mellitus, Type 1/epidemiology ; Diabetic Angiopathies/blood* ; Diabetic Angiopathies/diagnosis* ; Diabetic Angiopathies/epidemiology ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Microvessels/metabolism* ; Microvessels/pathology ; Middle Aged ; Retrospective Studies ; Risk Factors ; Serum Albumin/metabolism*
Type 1 diabetes ; Glycated albumin ; Diabetic nephropathy ; Carotid artery atherosclerosis
BACKGROUND: We investigated the relationship between the glycemic indices glycated albumin (GA) and glycated hemoglobin (HbA1c) and the progression of diabetic vascular complications [diabetic nephropathy (DN) and carotid artery atherosclerosis (CAA)] in subjects with type 1 diabetes (T1D). METHODS: A total of 154 participants with a median follow-up of 2.8 years were enrolled in this retrospective longitudinal study. We recruited T1D subjects who had regularly measured urine albumin-creatinine ratios and estimated glomerular filtration rates, as well as tested HbA1c and GA levels consecutively every 3 or 6 months. A subgroup of 54 subjects was measured repeated carotid intima-media thickness (IMT). RESULTS: We classified subjects into the DN progression (Group I; n = 30) with either deteriorated stages of chronic kidney disease (n = 18) or albuminuria progression (n = 17), and the non-progression (Group II; n = 124). In multiple logistic regression analyses, baseline albuminuria (odds ratio [OR] = 2.64, 95 % confidence interval [CI] = 1.03-6.74), mean GA levels (OR = 2.03, 95 % CI = 1.27-3.26) were significantly associated with progression of DN. However, there was no association with mean HbA1c (OR = 0.98, 95 % CI = 0.62-1.54). In a subgroup analysis for follow-up measurements of carotid IMT, age was independently associated with the presence of plaque and the mean IMT. However glycemic indices were not significantly associated with CAA. CONCLUSIONS: Mean GA levels were more closely associated with DN progression than mean HbA1c in subjects with T1D. However, they were not associated with the CAA.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, So Ra(김소라)
Yoon, Hye Jin(윤혜진)
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Eun Young(이은영)
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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