Cited 22 times in
Glycated albumin and the risk of micro- and macrovascular complications in subjects with type 1 diabetes
DC Field | Value | Language |
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dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 김소라 | - |
dc.contributor.author | 윤혜진 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 이은영 | - |
dc.contributor.author | 임형택 | - |
dc.contributor.author | 강은석 | - |
dc.date.accessioned | 2016-02-04T11:23:14Z | - |
dc.date.available | 2016-02-04T11:23:14Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140311 | - |
dc.description.abstract | BACKGROUND: We investigated the relationship between the glycemic indices glycated albumin (GA) and glycated hemoglobin (HbA1c) and the progression of diabetic vascular complications [diabetic nephropathy (DN) and carotid artery atherosclerosis (CAA)] in subjects with type 1 diabetes (T1D). METHODS: A total of 154 participants with a median follow-up of 2.8 years were enrolled in this retrospective longitudinal study. We recruited T1D subjects who had regularly measured urine albumin-creatinine ratios and estimated glomerular filtration rates, as well as tested HbA1c and GA levels consecutively every 3 or 6 months. A subgroup of 54 subjects was measured repeated carotid intima-media thickness (IMT). RESULTS: We classified subjects into the DN progression (Group I; n = 30) with either deteriorated stages of chronic kidney disease (n = 18) or albuminuria progression (n = 17), and the non-progression (Group II; n = 124). In multiple logistic regression analyses, baseline albuminuria (odds ratio [OR] = 2.64, 95 % confidence interval [CI] = 1.03-6.74), mean GA levels (OR = 2.03, 95 % CI = 1.27-3.26) were significantly associated with progression of DN. However, there was no association with mean HbA1c (OR = 0.98, 95 % CI = 0.62-1.54). In a subgroup analysis for follow-up measurements of carotid IMT, age was independently associated with the presence of plaque and the mean IMT. However glycemic indices were not significantly associated with CAA. CONCLUSIONS: Mean GA levels were more closely associated with DN progression than mean HbA1c in subjects with T1D. However, they were not associated with the CAA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carotid Intima-Media Thickness/trends | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/blood* | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/diagnosis* | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/epidemiology | - |
dc.subject.MESH | Diabetic Angiopathies/blood* | - |
dc.subject.MESH | Diabetic Angiopathies/diagnosis* | - |
dc.subject.MESH | Diabetic Angiopathies/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microvessels/metabolism* | - |
dc.subject.MESH | Microvessels/pathology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Serum Albumin/metabolism* | - |
dc.title | Glycated albumin and the risk of micro- and macrovascular complications in subjects with type 1 diabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hye-jin Yoon | - |
dc.contributor.googleauthor | Yong-ho Lee | - |
dc.contributor.googleauthor | So Ra Kim | - |
dc.contributor.googleauthor | Tyler Hyungtaek Rim | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | , Eun Seok Kang | - |
dc.contributor.googleauthor | Bong-Soo Cha | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.identifier.doi | 10.1186/s12933-015-0219-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A00612 | - |
dc.contributor.localId | A02624 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03042 | - |
dc.relation.journalcode | J00460 | - |
dc.identifier.eissn | 1475-2840 | - |
dc.identifier.pmid | 25975731 | - |
dc.subject.keyword | Type 1 diabetes | - |
dc.subject.keyword | Glycated albumin | - |
dc.subject.keyword | Diabetic nephropathy | - |
dc.subject.keyword | Carotid artery atherosclerosis | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Kim, So Ra | - |
dc.contributor.alternativeName | Yoon, Hye Jin | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.alternativeName | Lee, Eung Young | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kim, So Ra | - |
dc.contributor.affiliatedAuthor | Yoon, Hye Jin | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Eun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 53 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, Vol.14 : 53, 2015 | - |
dc.identifier.rimsid | 50422 | - |
dc.type.rims | ART | - |
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