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Enhancement of human mesenchymal stem cell infiltration into the electrospun poly(lactic-co-glycolic acid) scaffold by fluid shear stress

Authors
 Min Sung Kim  ;  Mi Hee Lee  ;  Byeong-Ju Kwon  ;  Min-Ah Koo  ;  Gyeung Mi Seon  ;  Jong-Chul Park 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.463(1~2) : 137-142, 2015 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2015
MeSH
Biocompatible Materials/chemistry ; Cell Movement ; Cells, Cultured ; Humans ; Hydrodynamics ; Lactic Acid/chemistry* ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/physiology* ; Microscopy, Electron, Scanning ; Polyglycolic Acid/chemistry* ; Tissue Engineering/instrumentation ; Tissue Scaffolds/chemistry*
Keywords
Cell infiltration ; Fluid shear stress ; Human mesenchymal stem cell ; Mechanotaxis ; PLGA scaffold
Abstract
The infiltration of the cells into the scaffolds is important phenomenon to give them good biocompatibility and even biodegradability. Fluid shear stress is one of the candidates for the infiltration of cells into scaffolds. Here we investigated the directional migration of human mesenchymal stem cells and infiltration into PLGA scaffold by fluid shear stress. The human mesenchymal stem cells showed directional migrations following the direction of the flow (8, 16 dyne/cm(2)). In the scaffold models, the fluid shear stress (8 dyne/cm(2)) enhanced the infiltration of cells but did not influence on the infiltration of Poly(lactic-co-glycolic acid) particles.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X1500964X
DOI
10.1016/j.bbrc.2015.05.048.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Koo, Min-Ah(구민아) ORCID logo https://orcid.org/0000-0002-8671-1131
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Kim, Min Sung(김민성)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Seon, Gyeung Mi(선경미) ORCID logo https://orcid.org/0000-0002-0766-1106
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140301
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