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Chlorhexidine-releasing orthodontic elastomerics

Authors
 Hyun-Sun JEON  ;  Choong-Ho CHOI  ;  Si-Mook KANG  ;  Ho-Keun KWON  ;  Baek-Il KIM 
Citation
 DENTAL MATERIALS JOURNAL, Vol.34(3) : 321-326, 2015 
Journal Title
DENTAL MATERIALS JOURNAL
ISSN
 0287-4547 
Issue Date
2015
MeSH
Anti-Infective Agents, Local/administration & dosage* ; Anti-Infective Agents, Local/pharmacology* ; Chlorhexidine/administration & dosage* ; Chlorhexidine/pharmacology* ; Delayed-Action Preparations ; Drug Delivery Systems ; Materials Testing ; Orthodontics/instrumentation* ; Polymers/chemistry* ; Solvents/chemistry ; Spectrophotometry ; Streptococcus mutans/drug effects ; Surface Properties ; Tensile Strength
Keywords
Chlorhexidine ; Drug release system ; Elastomeric ; Polymer
Abstract
The aim of this study was to identify the best combination of chlorhexidine (CHX) with orthodontic elastomerics for prevention of oral disease in orthodontic patients. We used ethyl cellulose (EC) as the polymer, and experimental groups were divided into five groups according to differences in solvent (i.e., ethanol; EtOH, dichloromethane; DCM). CHX release from the coated elastomerics was evaluated with a UV spectrophotometer and observed by scanning electron microscope (SEM). The antimicrobial release increased over time for 48 h in Group 3 (CDA+EC+30% EtOH/70% DCM), exhibiting the longest sustained-release characteristics (p<0.001). It also showed the highest antimicrobial properties, which was confirmed by inhibition zone testing using S. mutans (p<0.05). All groups were not affected when tensile force was tested in the coated elastomerics. We conclude that the antibacterial effect of CHX can be adjusted according to combinations of polymers and solvents. Group 3 exhibited the best substantivity and antimicrobial properties.
Files in This Item:
T201501740.pdf Download
DOI
10.4012/dmj.2014-216
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kang, Si-Mook(강시묵) ORCID logo https://orcid.org/0000-0003-2341-3636
Kwon, Ho Keun(권호근)
Kim, Baek Il(김백일) ORCID logo https://orcid.org/0000-0001-8234-2327
Jeon, Hyun Sun(전현선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140273
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