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Fine-needle aspirate CYFRA 21-1, an innovative new marker for diagnosis of axillary lymph node metastasis in breast cancer patients

DC Field Value Language
dc.contributor.author김민정-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author윤정현-
dc.contributor.author한경화-
dc.contributor.author최지수-
dc.date.accessioned2016-02-04T11:21:29Z-
dc.date.available2016-02-04T11:21:29Z-
dc.date.issued2015-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140246-
dc.description.abstractTo compare the value of cytokeratin fragment 21-1 (CYFRA 21-1) concentration in the fine-needle biopsy aspirates (fine needle aspirate [FNA] CYFRA 21-1) with cytopathology of fine-needle aspiration biopsy (FNA cytology) and to assess whether CYFRA 21-1 concentrations from ultrasound-guided fine-needle aspiration biopsy (US-FNAB) specimens (FNA CYFRA 21-1) is not inferior to FNA cytology in the diagnosis of axillary lymph node (ALN) metastasis of breast cancer patients.This study received institutional review board approval, and written informed consent was obtained from all patients. US-FNAB was performed in 373 ALNs from 358 patients with invasive breast cancer. Concentrations of CYFRA 21-1 were measured from washouts of the syringe used during US-FNAB (FNA CYFRA 21-1), and ALN metastasis was determined using a cutoff value of 1.93 ng/mL. FNA cytology, intraoperative sentinel lymph node biopsy, and surgical pathology results were reviewed and analyzed. The noninferiority margin for the difference in accuracies between FNA cytology and FNA CYFRA 21-1 was set as 5%.Among 373 ALNs, 136 (36.5%) were benign, and 237 (63.5%) were metastatic. The mean FNA CYFRA 21-1 was significantly higher in metastatic ALNs compared to that in benign ALNs (P = 0.001). For the diagnosis of ALN metastasis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FNA CYFRA 21-1 (cutoff value 1.93 ng/mL) were not significantly different from those of FNA cytology (P > 0.05). FNA CYFRA 21-1 reached statistical noninferiority to FNA cytology in terms of diagnostic accuracy for ALN metastasis. Of the 20 ALNs (8 metastasis, 12 benign) that showed insufficient results on FNA cytology, FNA CYFRA 21-1 accurately diagnosed 15 ALNs (4 metastasis, 11 benign).The diagnostic performance of FNA CYFRA 21-1 is comparable with that of FNA cytology for breast cancer ALN metastasis. Our results indicate that FNA CYFRA 21-1, using an US-FNAB specimen, can be a useful method equal to FNA cytology in terms of diagnostic accuracy.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntigens, Neoplasm/analysis*-
dc.subject.MESHAxilla-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHBiopsy, Fine-Needle-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHBreast Neoplasms/surgery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKeratin-19/analysis*-
dc.subject.MESHLymph Nodes/pathology*-
dc.subject.MESHLymph Nodes/surgery-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHSentinel Lymph Node Biopsy-
dc.subject.MESHUltrasonography, Interventional-
dc.titleFine-needle aspirate CYFRA 21-1, an innovative new marker for diagnosis of axillary lymph node metastasis in breast cancer patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorJi Soo Choi-
dc.contributor.googleauthorKyung Hwa Han-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorMin Jung Kim-
dc.identifier.doi10.1097/MD.0000000000000811-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00473-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA02595-
dc.contributor.localIdA04267-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid25984666-
dc.contributor.alternativeNameKim, Min Jung-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.alternativeNameHan, Kyung Hwa-
dc.contributor.affiliatedAuthorKim, Min Jung-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.contributor.affiliatedAuthorHan, Kyung Hwa-
dc.rights.accessRightsfree-
dc.citation.volume94-
dc.citation.number19-
dc.citation.startPage811-
dc.identifier.bibliographicCitationMEDICINE, Vol.94(19) : 811, 2015-
dc.identifier.rimsid50374-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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