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소아 급성림프모구백혈병에서 CDH1 , p16 , DAPK 유전자의 DNA 메틸화

Other Titles
 Aberrant DNA Methylation of CDH1, p16 and DAPK in Childhood Acute Lymphoblastic Leukemia 
 한승민  ;  권승연  ;  김효선  ;  한정우  ;  유철주 
 Clinical Pediatric Hematology-Oncology, Vol.22(1) : 60-66, 2015 
Journal Title
 Clinical Pediatric Hematology-Oncology 
Issue Date
Background: Hypermethylation of tumor suppressor gene has been reported in various types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. Methods: To evaluate the methylation status at initial diagnosis and morphologic complete remission (CR) period in childhood acute lymphoblastic leukemia (ALL), we analyzed the methylation status of three key genes (CDH1, p16 and DAPK) in 43 childhood ALL patients and 7 healthy bone marrow (BM) donors. Results: CDH1 was methylated in 26 (60.4%) patients, p16 in two (4.6%) patients and DAPK in six (13.9%) patients at the time of diagnosis. Twenty nine (67.4%) patients had methylation of at least one gene. None of the healthy BM donors showed methylation of the above genes. Age was the only factor which showed significant association with the presence of DNA methylation (P=0.03). None of the other clinicopathological factors showed association with initial methylation status. At the time of morphologic CR, all patients who had aberrant DNA methylation at the time of diagnosis had no detectable residual methylation. Conclusion: Since hypermethylation was found in around two thirds of pretreatment ALL patients and none in healthy BM donor, we suggest hypermethylation of some important genes is a biologic marker of childhood ALL. We recommend that further studies with a large number of patients should be conducted.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
권승연(Kwon, Seung Yeon)
김효선(Kim, Hyo Sun)
유철주(Lyu, Chuhl Joo) ORCID logo https://orcid.org/0000-0001-7124-7818
한승민(Hahn, Seung Min) ORCID logo https://orcid.org/0000-0001-9832-6380
한정우(Han, Jung Woo) ORCID logo https://orcid.org/0000-0001-8936-1205
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