138 406

Cited 0 times in

소아 급성림프모구백혈병에서 CDH1 , p16 , DAPK 유전자의 DNA 메틸화

DC FieldValueLanguage
dc.contributor.author권승연-
dc.contributor.author김효선-
dc.contributor.author유철주-
dc.contributor.author한승민-
dc.contributor.author한정우-
dc.date.accessioned2016-02-04T11:18:11Z-
dc.date.available2016-02-04T11:18:11Z-
dc.date.issued2015-
dc.identifier.issn2233-5250-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140123-
dc.description.abstractBackground: Hypermethylation of tumor suppressor gene has been reported in various types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. Methods: To evaluate the methylation status at initial diagnosis and morphologic complete remission (CR) period in childhood acute lymphoblastic leukemia (ALL), we analyzed the methylation status of three key genes (CDH1, p16 and DAPK) in 43 childhood ALL patients and 7 healthy bone marrow (BM) donors. Results: CDH1 was methylated in 26 (60.4%) patients, p16 in two (4.6%) patients and DAPK in six (13.9%) patients at the time of diagnosis. Twenty nine (67.4%) patients had methylation of at least one gene. None of the healthy BM donors showed methylation of the above genes. Age was the only factor which showed significant association with the presence of DNA methylation (P=0.03). None of the other clinicopathological factors showed association with initial methylation status. At the time of morphologic CR, all patients who had aberrant DNA methylation at the time of diagnosis had no detectable residual methylation. Conclusion: Since hypermethylation was found in around two thirds of pretreatment ALL patients and none in healthy BM donor, we suggest hypermethylation of some important genes is a biologic marker of childhood ALL. We recommend that further studies with a large number of patients should be conducted.-
dc.description.statementOfResponsibilityopen-
dc.format.extent60~66-
dc.relation.isPartOfClinical Pediatric Hematology-Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title소아 급성림프모구백혈병에서 CDH1 , p16 , DAPK 유전자의 DNA 메틸화-
dc.title.alternativeAberrant DNA Methylation of CDH1, p16 and DAPK in Childhood Acute Lymphoblastic Leukemia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthor한승민-
dc.contributor.googleauthor권승연-
dc.contributor.googleauthor김효선-
dc.contributor.googleauthor한정우-
dc.contributor.googleauthor유철주-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04325-
dc.contributor.localIdA00226-
dc.contributor.localIdA01201-
dc.contributor.localIdA02524-
dc.contributor.localIdA04299-
dc.relation.journalcodeJ00605-
dc.contributor.alternativeNameKwon, Seung Yeon-
dc.contributor.alternativeNameKim, Hyo Sun-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameHahn, Seung Min-
dc.contributor.alternativeNameHan, Jung Woo-
dc.contributor.affiliatedAuthorHan, Jung Woo-
dc.contributor.affiliatedAuthorKwon, Seung Yeon-
dc.contributor.affiliatedAuthorKim, Hyo Sun-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorHahn, Seung Min-
dc.rights.accessRightsfree-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage60-
dc.citation.endPage66-
dc.identifier.bibliographicCitationClinical Pediatric Hematology-Oncology, Vol.22(1) : 60-66, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.