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A hierarchical cluster analysis of normal-tension glaucoma using spectral-domain optical coherence tomography parameters

 Hyoung Won Bae  ;  Yongwoo Ji  ;  Hye Sun Lee  ;  Naeun Lee  ;  Samin Hong  ;  Gong Je Seong  ;  Kyung Rim Sung  ;  Chan Yun Kim 
 JOURNAL OF GLAUCOMA, Vol.24(4) : 328-333, 2015 
Journal Title
Issue Date
Adult ; Cluster Analysis ; Female ; Humans ; Intraocular Pressure ; Low Tension Glaucoma/classification* ; Low Tension Glaucoma/diagnosis ; Male ; Middle Aged ; Nerve Fibers/pathology* ; Optic Disk/pathology* ; Optic Nerve Diseases/classification* ; Optic Nerve Diseases/diagnosis ; Retinal Ganglion Cells/pathology* ; Tomography, Optical Coherence/methods
normal-tension glaucoma ; hierarchical cluster analysis ; spectral domain optical coherence tomography
PURPOSE: Normal-tension glaucoma (NTG) is a heterogenous disease, and there is still controversy about subclassifications of this disorder. On the basis of spectral-domain optical coherence tomography (SD-OCT), we subdivided NTG with hierarchical cluster analysis using optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thicknesses. PATIENTS AND METHODS: A total of 200 eyes of 200 NTG patients between March 2011 and June 2012 underwent SD-OCT scans to measure ONH parameters and RNFL thicknesses. We classified NTG into homogenous subgroups based on these variables using a hierarchical cluster analysis, and compared clusters to evaluate diverse NTG characteristics. RESULTS: Three clusters were found after hierarchical cluster analysis. Cluster 1 (62 eyes) had the thickest RNFL and widest rim area, and showed early glaucoma features. Cluster 2 (60 eyes) was characterized by the largest cup/disc ratio and cup volume, and showed advanced glaucomatous damage. Cluster 3 (78 eyes) had small disc areas in SD-OCT and were comprised of patients with significantly younger age, longer axial length, and greater myopia than the other 2 groups. CONCLUSIONS: A hierarchical cluster analysis of SD-OCT scans divided NTG patients into 3 groups based upon ONH parameters and RNFL thicknesses. It is anticipated that the small disc area group comprised of younger and more myopic patients may show unique features unlike the other 2 groups.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Na Eun(이나은)
Ji, Yong Woo(지용우)
Hong, Sa Min(홍사민)
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