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A network analysis of ¹⁵O-H₂O PET reveals deep brain stimulation effects on brain network of Parkinson's disease

Authors
 Hae-Jeong Park  ;  Bumhee Park  ;  Hae Yu Kim  ;  Maeng-Keun Oh  ;  Joong Il Kim  ;  Misun Yoon  ;  Jong Doo Lee  ;  Jin Woo Chang 
Citation
 YONSEI MEDICAL JOURNAL, Vol.56(3) : 726-736, 2015 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2015
MeSH
Aged ; Brain/diagnostic imaging* ; Cross-Sectional Studies ; Deep Brain Stimulation/methods* ; Female ; Functional Laterality/physiology* ; Humans ; Male ; Middle Aged ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/therapy* ; Positron-Emission Tomography ; Severity of Illness Index ; Subthalamic Nucleus/physiopathology*
Keywords
Deep brain stimulation ; H₂O PET ; Parkinson's disease ; brain networks ; independent component analysis
Abstract
PURPOSE: As Parkinson's disease (PD) can be considered a network abnormality, the effects of deep brain stimulation (DBS) need to be investigated in the aspect of networks. This study aimed to examine how DBS of the bilateral subthalamic nucleus (STN) affects the motor networks of patients with idiopathic PD during motor performance and to show the feasibility of the network analysis using cross-sectional positron emission tomography (PET) images in DBS studies. MATERIALS AND METHODS: We obtained [¹⁵O]H₂O PET images from ten patients with PD during a sequential finger-to-thumb opposition task and during the resting state, with DBS-On and DBS-Off at STN. To identify the alteration of motor networks in PD and their changes due to STN-DBS, we applied independent component analysis (ICA) to all the cross-sectional PET images. We analysed the strength of each component according to DBS effects, task effects and interaction effects. RESULTS: ICA blindly decomposed components of functionally associated distributed clusters, which were comparable to the results of univariate statistical parametric mapping. ICA further revealed that STN-DBS modifies usage-strengths of components corresponding to the basal ganglia-thalamo-cortical circuits in PD patients by increasing the hypoactive basal ganglia and by suppressing the hyperactive cortical motor areas, ventrolateral thalamus and cerebellum. CONCLUSION: Our results suggest that STN-DBS may affect not only the abnormal local activity, but also alter brain networks in patients with PD. This study also demonstrated the usefulness of ICA for cross-sectional PET data to reveal network modifications due to DBS, which was not observable using the subtraction method.
Files in This Item:
T201501322.pdf Download
DOI
10.3349/ymj.2015.56.3.726
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joong Il(김중일)
Kim, Hae Yu(김해유)
Park, Bum Hee(박범희)
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Lee, Jong Doo(이종두)
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140025
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