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Parathyroid hormone, calcium, and sodium bridging between osteoporosis and hypertension in postmenopausal Korean women

 Jee Soo Park  ;  Soo Beom Choi  ;  Yumie Rhee  ;  Jai Won Chung  ;  Eui-Young Choi  ;  Deok Won Kim 
 Calcified Tissue International, Vol.96(5) : 417-429, 2015 
Journal Title
 Calcified Tissue International 
Issue Date
The coexistence of osteoporosis and hypertension, which are considered distinct diseases, has been widely reported. In addition, daily intake of calcium and sodium, as well as parathyroid hormone levels (PTH), is known to be associated with osteoporosis and hypertension. This study aimed to determine the association of low calcium intake, high sodium intake, and PTH levels with osteoporosis and hypertension in postmenopausal Korean women. Data for postmenopausal Korean women aged 50 years or older were obtained from the Korea National Health and Nutrition Examination Survey 2008-2011. Osteoporosis was diagnosed using dual energy X-ray absorptiometry, while hypertension was diagnosed using blood pressure data. The odds ratios for osteoporosis and hypertension were calculated using logistic regression analysis for quartiles of the daily calcium intake, daily sodium intake, and PTH levels. Women with hypertension had a high coexistence of osteoporosis (43.6 vs. 36.5 %; P = 0.022), and vice versa (21.1 vs. 16.6 %; P = 0.022). PTH was significantly associated with osteoporosis and hypertension, and a high intake of calcium was strongly correlated with a low incidence of osteoporosis. This is the first study to report the characteristics of postmenopausal Korean women who have high dietary sodium intake and low dietary calcium intake, in association with the incidence of osteoporosis and hypertension. Osteoporosis and hypertension were strongly associated with each other, and PTH appears to be a key mediator of both diseases, suggesting a possible pathogenic link.
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1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김덕원(Kim, Deok Won)
박지수(Park, Jee Soo) ORCID logo https://orcid.org/0000-0001-9976-6599
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
정재원(Chung, Jai Won)
최수범(Choi, Soo Beom)
최의영(Choi, Eui Young) ORCID logo https://orcid.org/0000-0003-3732-0190
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