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miR-155 is involved in Alzheimer's disease by regulating T lymphocyte function

Authors
 Juhyun Song  ;  Jong Eun Lee 
Citation
 FRONTIERS IN AGING NEUROSCIENCE, Vol.7 : 61, 2015 
Journal Title
 FRONTIERS IN AGING NEUROSCIENCE 
Issue Date
2015
Keywords
Alzheimer’s disease (AD) ; T lymphocyte (T-cell) ; immunity ; micro RNA-155 (miR-155)
Abstract
Alzheimer's disease (AD) is considered the most common cause of sporadic dementia. In AD, adaptive and innate immune responses play a crucial role in clearance of amyloid beta and maintenance of cognitive functions. In addition to other changes in the immune system, AD alters the T-cell responses that affect activation of glial cells, neuronal cells, macrophages, and secretion of pro-inflammatory cytokines. These changes in the immune system influence AD pathogenesis. Micro-RNA (miRNA)-155 is a multifunctional miRNA with a distinct expression profile. It is involved in diverse physiological and pathological mechanisms, such as immunity and inflammation. Recent studies indicate that miR-155 regulates T-cell functions during inflammation. In this article, we summarize recent studies describing the therapeutic potential of miR-155 via regulation of T cells in AD. Further, we propose that regulation of miR-155 might be a new protective approach against AD pathogenesis.
Files in This Item:
T201501273.pdf Download
DOI
10.3389/fnagi.2015.00061
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Song, Ju Hyun(송주현)
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139993
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