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Olfactory performance and resting state functional connectivity in non-demented drug naïve patients with Parkinson's disease

 Mun Kyung Sunwoo  ;  Jungho Cha  ;  Jee Hyun Ham  ;  Sook K. Song  ;  Jin Yong Hong  ;  Jong-Min Lee  ;  Young H. Sohn  ;  Phil Hyu Lee 
 HUMAN BRAIN MAPPING, Vol.36(5) : 1716-1727, 2015 
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Aged ; Brain/pathology ; Brain/physiopathology* ; Brain Mapping ; Female ; Humans ; Male ; Middle Aged ; Neural Pathways/pathology ; Neural Pathways/physiopathology ; Neuropsychological Tests ; Olfactory Perception/physiology* ; Parkinson Disease/pathology ; Parkinson Disease/physiopathology* ; Rest
Parkinson's disease ; cognition ; olfaction ; resting state functional connectivity
Olfactory performance in Parkinson's disease (PD) is closely associated with subsequent cognitive decline. In the present study, we analyzed the olfaction-dependent functional connectivity with a hypothesis that olfactory performance would influence functional connectivity within key brain areas of PD. A total of 110 nondemented drug-naïve patients with PD were subdivided into three groups of high score (PD-H, n = 23), middle score (PD-M, n = 64), and low score (PD-L, n = 23) based on olfactory performance. We performed the resting-state functional connectivity with seed region of interest in the posterior cingulate cortex (PCC) and caudate. An analysis of functional connectivity revealed that PD-L patients exhibited a significant attenuation of cortical functional connectivity with the PCC in the bilateral primary sensory areas, right frontal areas, and right parietal areas compared to PD-H or PD-M patients. Meanwhile, PD-L patients exhibited a significant enhancement of striatocortical functional connectivity in the bilateral occipital areas and right frontal areas compared to PD-H or PD-M patients. In the voxel-wise correlation analysis, olfactory performance was positively associated with cortical functional connectivity with the PCC in similar areas of attenuated cortical connectivity in PD-L patients relative to PD-H patients. On the other hand, the cortical functional connectivity with the caudate was negatively correlated with olfactory performance in similar areas of increased connectivity in PD-L patients relative to PD-H patients. The present study demonstrated that resting state functional connectivity exhibits a distinctive pattern depending on olfactory performance, which might shed light on a meaningful relationship between olfactory impairment and cognitive dysfunction in PD.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Ham, Jee Hyun(함지현)
Hong, Jin Yong(홍진용)
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